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The murine Irs1 knockout model, generated by the spontaneous Irs1S57X mutation in homozygosity, exhibits high embryonic lethality, limiting studies of adult hematopoiesis

Crossref DOI link: https://doi.org/10.1016/j.htct.2026.106465

Published Print: 2026-07

Update policy: https://doi.org/10.1016/elsevier_cm_policy

Authors

Fenerich, Bruna Alves https://orcid.org/0000-0003-2267-5626
Fernandes, Jaqueline Cristina

Silva, Cleide Lúcia Araújo https://orcid.org/0000-0002-7841-3652
Machado-Neto, João Agostinho https://orcid.org/0000-0002-2937-8109
Traina, Fabiola https://orcid.org/0000-0003-4258-289X
Funding

Funding for this research was provided by:

Conselho Nacional de Desenvolvimento Científico e Tecnológico (465539/2014-9)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (408553/2024-3)

State of Sao Paulo Research Foundation (2017/19864-6)

State of Sao Paulo Research Foundation (2013/08135-2)

State of Sao Paulo Research Foundation (2017/25068-8)

State of Sao Paulo Research Foundation (2014/50947-7)

Coordination for the improvement of Higher Education Personnel
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Text and Data Mining valid from 2026-07-01

Version of Record valid from 2026-04-10
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Article Title: The murine Irs1 knockout model, generated by the spontaneous Irs1S57X mutation in homozygosity, exhibits high embryonic lethality, limiting studies of adult hematopoiesis

Journal Title: Hematology, Transfusion and Cell Therapy

CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.htct.2026.106465

Content Type: article

Copyright: © 2026 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier España, S.L.U.

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