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Authors
Melero, Ignacio
Calvo, Emiliano
Goebeler, Maria-Elisabeth
Garralda, Elena
Dummer, Reinhard
Rodríguez-Ruiz, María
Miguel, Maria de
Sayehli, Cyrus Michael
Casal, Guzman Alonso
Ramelyte, Egle
Schuler, Martin
Gromke, Tanja
Sanmamed, Miguel
Moreno, Irene
Bargou, Ralf
Lostes, Maria
Maul, Julia-Tatjana
Eggenschwiler, Corinne
Richly, Heike
Fettes, Petra
Klar, Kathrin
Schuberth-Wagner, Christine
Haake, Markus
Wischhusen, Jörg
Leo, Eugen
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Clinical Trials BETA
Clinical trials referenced in this document:
nct04725474 at ClinicalTrials.govDocuments that mention this clinical trial
519 GDFATHER-01 trial longterm follow-up: GDF-15 neutralization combined with nivolumab can enable deep, longterm remission in heavily pretreated, anti-PD1/-L1 relapsed/refractory major solid tumor types
https://doi.org/10.1136/jitc-2025-sitc2025.0519
03.04 Targeted disruption of tumor-borne GDF-15-mediated immunoresistance restores immune checkpoint inhibitor activity in last-line cancer patients
https://doi.org/10.1136/jitc-2024-itoc10.2
568 Tumor-derived GDF-15 prevents therapy success of checkpoint inhibitors by blocking T-lymphocyte recruitment
https://doi.org/10.1136/jitc-2021-sitc2021.568
Interplay between sarcopenia, GDF-15, and the efficacy of nivolumab plus ipilimumab in patients with mismatch repair deficient metastatic colorectal cancer: final survival analysis of the phase II GERCOR NIPICOL study
https://doi.org/10.1136/jitc-2024-011220
Effects of neutralization of tumor-derived immunosuppressant GDF-15 on anti-PD-1 activity in anti-PD-(L)1 relapsed/refractory non-squamous NSCLC, urothelial, and hepatocellular cancer.
https://doi.org/10.1200/jco.2024.42.16_suppl.2513
1196 GDF-15 neutralizing antibody visugromab increases intratumoral immune cell infiltration to support bispecific T-cell engagers
https://doi.org/10.1136/jitc-2023-sitc2023.1196
Initial results from the phase 2A trial of visugromab (CTL-002) + nivolumab in advanced/metastatic anti-PD1/-L1 relapsed/refractory solid tumors (The GDFATHER-TRIAL).
https://doi.org/10.1200/jco.2023.41.16_suppl.2501
504 A phase I, first-in-human clinical trial of the GDF-15 neutralizing antibody CTL-002 in subjects with advanced stage solid tumors (Acronym: GDFATHER)
https://doi.org/10.1136/jitc-2021-sitc2021.504
1049 SHP-1 is a central mediator of GDF-15 mediated adhesion inhibition in T-cells
https://doi.org/10.1136/jitc-2023-sitc2023.1049
P-01.16 GDF-15 inhibition overcomes treatment resistance to platinum-based chemoimmunotherapy
https://doi.org/10.1136/jitc-2025-itoc11.23
Distinct single-cell immune ecosystems distinguish true and de novo HBV-related hepatocellular carcinoma recurrences
https://doi.org/10.1136/gutjnl-2022-328428
