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Multi-dimensional plasma proteomic profiling elucidates molecular mechanisms and pathophysiological networks in pediatric severe traumatic brain injury

Crossref DOI link: https://doi.org/10.1007/s00011-026-02209-6

Published Online: 2026-03-27

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Cela, Enis

Tweddell, David

Daley, Mark

Morello, Maria

Cepinskas, Gediminas

Fraser, Douglas D.
Funding

Funding for this research was provided by:

Academic Medical Organization of Southwestern Ontario

Children's Health Foundation

GSK Chair in Clinical Pharmacology
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Text and Data Mining valid from 2026-03-27

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Article History

Received: 31 October 2025

Revised: 13 February 2026

Accepted: 14 February 2026

First Online: 27 March 2026

Declarations

:

: The authors declare no competing interests.

: This study was approved by the Western University, Human Research Ethics Board (HREB; #17908E; #15996E). Consent was obtained from the legal guardians of all pediatric patients admitted with sTBI, and both guardian consent and patient assent were secured for healthy control participants.

: Not applicable.

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