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Multivariable genome-wide analysis elucidates the shared genetic architecture, immunosenescence features, and gut-origin therapeutic targets of ulcerative colitis-associated multisystem inflammation

Crossref DOI link: https://doi.org/10.1007/s00011-026-02257-y

Published Online: 2026-05-07

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Tang, Shanneng

Yao, Xin

Wang, Shanshan

Zhu, Fanfan

Zeng, Wenbin

Lai, Dongping

Meng, Xiaobing

Zhang, Xinyue

Zhu, Ziming

Zhang, Tao

Xu, Ri’an
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Text and Data Mining valid from 2026-05-07

Version of Record valid from 2026-05-07
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Article History

Received: 4 November 2025

Revised: 20 March 2026

Accepted: 15 April 2026

First Online: 7 May 2026

Declarations

:

: The authors declare no competing interests.

: This study exclusively utilized publicly available summary statistics from previously published GWAS and publicly accessible databases, including UK Biobank, FinnGen, GTEx Project, and GEO. All original studies received ethical approval from their respective Institutional Review Boards, and informed consent was obtained from all participants in the primary studies. No new human subjects, human data, or human tissues were directly involved in this secondary analysis. As this research involved only the analysis of de-identified, publicly available summary-level data, no additional ethical approval was required for the present study.

: Not applicable. This manuscript does not contain data from any individual person.

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