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Localization matters: nuclear-trapped Survivin sensitizes glioblastoma cells to temozolomide by elevating cellular senescence and impairing homologous recombination

Crossref DOI link: https://doi.org/10.1007/s00018-021-03864-0

Published Online: 2021-06-08

Published Print: 2021-07

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Reich, Thomas R.

Schwarzenbach, Christian

Vilar, Juliana Brandstetter

Unger, Sven

Mühlhäusler, Fabian

Nikolova, Teodora

Poplawski, Alicia

Baymaz, H. Irem

Beli, Petra

Christmann, Markus

Tomicic, Maja T. https://orcid.org/0000-0001-9289-4168
Funding

Funding for this research was provided by:

Deutsche Krebshilfe (70111404)

Deutsche Forschungsgemeinschaft (DFG-CH 665/6-1)

Wilhelm Sander-Stiftung (2019.154.1)

Stipendenstiftung Rheinland-Pfalz

Universitätsmedizin der Johannes Gutenberg-Universität Mainz
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Article History

Received: 25 January 2021

Revised: 20 May 2021

Accepted: 22 May 2021

First Online: 8 June 2021

Declarations

:

: The authors state no conflicts of interest.

: Investigations on the anonymized HGG patients’ samples (collected 2010–2013) were conducted according to the Declaration of Helsinki and approved by the authors’ institutional interdisciplinary neurological review board. Animal experiments were conducted with approval by the State Office of chemical investigations of Rhineland-Palatinate, Mainz, Germany (permission #23 177-07/G19-1-014).

: Written informed consent was provided by the participants via the Department of Neurosurgery, University Medical Center Mainz.

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