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Metabolic regulation of RA macrophages is distinct from RA fibroblasts and blockade of glycolysis alleviates inflammatory phenotype in both cell types

Crossref DOI link: https://doi.org/10.1007/s00018-021-03978-5

Published Online: 2021-10-27

Published Print: 2021-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Umar, Sadiq

Palasiewicz, Karol

Volin, Michael V.

Romay, Bianca

Rahat, Rani

Tetali, Chandana

Arami, Shiva

Guma, Monica

Ascoli, Christian

Sweiss, Nadera

Zomorrodi, Ryan K.

O’Neill, Luke A. J.

Shahrara, Shiva https://orcid.org/0000-0002-6698-8491
Funding

Funding for this research was provided by:

U.S. Department of Veterans Affairs (BX002286)

National Institutes of Health (AI147697)

National Psoriasis Foundation
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Article History

Received: 24 March 2021

Revised: 10 September 2021

Accepted: 13 October 2021

First Online: 27 October 2021

Declarations

:

: The authors have declared that no commercial or financial conflict of interest exists.

: All peripheral blood (PB) was collected in accordance with our protocol approved by the University of Illinois at Chicago Institutional Ethics Review Board. All the RA patients have consented to participate in this study and have provided written consent. Furthermore, all animal studies were approved by the University of Illinois at Chicago Animal Care and Use Committee following the legal requirements and guidelines of the state of Illinois in the USA and NIH.

: All authors have been involved in writing the manuscript and consented to publication.

: All findings are exhibited in the paper and the material and data are available for transparency.

: Not applicable.

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