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Authors
Conduit, Sarah E. https://orcid.org/0000-0002-5075-8851
Zhang, Cindy X. W. https://orcid.org/0000-0002-9705-1976
Pearce, Wayne https://orcid.org/0000-0001-5407-4767
Guillermet-Guibert, Julie https://orcid.org/0000-0003-3173-4907
Sferruzzi-Perri, Amanda N. https://orcid.org/0000-0002-4931-4233
Vanhaesebroeck, Bart https://orcid.org/0000-0002-7074-3673
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Funding
Funding for this research was provided by:
HORIZON EUROPE Framework Programme (838559)
Gates Cambridge Trust (OPP1144)
Biotechnology and Biological Sciences Research Council (BB/W007460/1)
Cancer Research UK (C23338/A25722)
Cancer Research UK (DRCRPG-Nov24/100006)
Medical Research Council (MR/R022690/1 / RG93186)
Lister Institute of Preventive Medicine (RG39692)
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Article History
Received: 10 July 2025
Revised: 11 September 2025
Accepted: 5 October 2025
First Online: 19 November 2025
Declarations
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: Mice were maintained at University College London according to Animals (Scientific Procedures) Act 1986 Amendment Regulations 2012 (approved by the Animal Welfare and Ethical Review Body (AWERB), P434BB714 and PP5281579).
: B.V. is a consultant for iOnctura (Geneva, Switzerland), Pharming (Leiden, the Netherlands) and a shareholder of Open Orphan and Poolbeg Pharma (Dublin, Ireland). The remaining authors have no relevant financial or non-financial interests to disclose.
