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Histone lactylation drives METTL3 upregulation-mediated RNA m6A modification of CCT2 to hinder CD8+ T cell survival in gastric cancer

Published Online: 2025-11-25

Authors

Qian, Zhenyuan

Cai, Xufan

Wu, Fang

Ye, Zaiyuan

Wu, Jianzhang https://orcid.org/0009-0004-1583-4240
Funding

Funding for this research was provided by:

Natural Science Foundation of Zhejiang Province (LY21H160053)

Key research fund of Hangzhou Medical College (KYZD2023011)
License Information

Text and Data Mining valid from 2025-11-25

Version of Record valid from 2025-12-29
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Article History

Received: 4 March 2025

Revised: 11 October 2025

Accepted: 16 October 2025

First Online: 25 November 2025

Declarations

:

: This study was approved by the Ethics Committee of Zhejiang Provincial People’s Hospital, approval number: 2024 (177) and the Animal Ethics Committee of Zhejiang Provincial People’s Hospital, approval number: 20240724114052566087.

: Written informed consent for publication was obtained from all participants.

: The authors declare that they have no competing interests.

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