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The food additive 4-hexylresorcinol impairs intestinal stem cell function and exacerbates inflammatory bowel disease in Drosophila melanogaster via suppression of mapk signaling pathway

Crossref DOI link: https://doi.org/10.1007/s00018-026-06159-4

Published Online: 2026-04-14

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Fan, Xinxin

Yan, Jinhua

Yuan, Yu

Chen, Yi

Chen, Haiyang https://orcid.org/0000-0001-8305-4060
Funding

Funding for this research was provided by:

Sichuan Science and Technology Program: Sichuan Provincial Natural Science Foundation (2025ZNSFSC0720)

the Noncommunicable Chronic Diseases-National Science and Technology Major Project (2023ZD0506800)

1·3·5 projects for Artificial Intelligence (ZYAI24024)
License Information

Text and Data Mining valid from 2026-04-14

Accepted Manuscript valid from 2026-04-14
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Article History

Received: 26 November 2025

Revised: 5 February 2026

Accepted: 19 February 2026

First Online: 14 April 2026

Declarations

:

: The animal study was approved by the Experimental Animal Ethics Committee of West China Hospital of Sichuan University. The study was conducted in accordance with the local legislation and institutional requirements.

: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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