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Authors
Jin, Heng https://orcid.org/0000-0001-9264-1187
Lin, Xiaoxi
Liu, Ziquan
Wang, Jinqiang
Wang, Jinxiang
Zhang, Yan
Cao, Chao
Chai, Yanfen
Shou, Songtao
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Funding
Funding for this research was provided by:
the national natural science foundation of china (82072222(HJ))
the fundamental research funds for the central universities (3332019127(Hj))
the science and technology fund of tianjin municipal health bureau (ZC20180(HJ))
the national key r&d program of china (2018YFC1504404)
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Article History
Received: 19 July 2021
Accepted: 29 January 2022
First Online: 28 February 2022
Declarations
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: The authors declare that they have no competing interests.
: All procedures were approved by the Institutional Animal Care and Use Committees from Tianjin Medical University General Hospital.
: Not applicable.
: Acute renal failure due to crush injury is one of the leading causes of death in disaster. Ischemic Postconditioning (IPC) was a potentially effective path to protect against ischemic reperfusion injury, but few studies noted the protective effect in crush induced AKI. Hence, this study investigated the optimal IPC strategy to prevent crush induced AKI and revealed related cellular mechanisms. Finally, we found that performing 5 cycles of 1-min IPC would be a convenient, time-saving and effective method to prevent crush induced AKI through attenuation of the release of nephrotoxic substance after decompression and down-regulation of the expression of apoptosis and cellular senescence, which will provide a novel path to intervene crush-induced AKI.
