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Authors
Hirsch, Scott D.
Elling, Christina L.
Bootpetch, Tori C.
Scholes, Melissa A.
Hafrén, Lena
Streubel, Sven-Olrik
Pine, Harold S.
Wine, Todd M.
Szeremeta, Wasyl
Prager, Jeremy D.
Einarsdottir, Elisabet
Yousaf, Ayesha
Baschal, Erin E.
Rehman, Sakina
Bamshad, Michael J.
Nickerson, Deborah A.
Riazuddin, Saima
Leal, Suzanne M.
Ahmed, Zubair M.
Yoon, Patricia J.
Kere, Juha
Chan, Kenny H.
Mattila, Petri S.
Friedman, Norman R.
Chonmaitree, Tasnee
Frank, Daniel N.
Ryan, Allen F.
Santos-Cortez, Regie Lyn P. https://orcid.org/0000-0002-9958-2535
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Funding
Funding for this research was provided by:
national heart, lung, and blood institute (U24 HG008956)
national institute on deafness and other communication disorders (T32 DC012280)
National Human Genome Research Institute (UM1 HG006493)
National Institute on Deafness and Other Communication Disorders (R01 DC015004)
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Article History
Received: 26 March 2021
Revised: 13 July 2021
Accepted: 14 July 2021
First Online: 28 July 2021
Change Date: 13 August 2021
Change Type: Update
Change Details: The original version of this article contained excess ESM file. The ESM file was now corrected.
Declarations
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: Human studies were approved by these institutional review boards (IRB): Bahauddin Zakariya University, Colorado Multiple IRB, Helsinki University Hospital, University of Maryland Baltimore, University of Minnesota, University of Texas Medical Branch, University of Virginia, and University of Washington. Informed consent was obtained from all study participants. Mouse studies were approved by the Institutional Animal Care and Use Committees of the Veterans Affairs Medical Center, San Diego.
: Dr. Allen Ryan is a co-founder of, shareholder in, and uncompensated consultant to Otonomy, Inc., a relationship that was approved by the University of California, San Diego. The authors declare no competing interests.
: ANNOVAR, annovar.openbioinformatics.orgBurrows-Wheeler Aligner, bio-bwa.sourceforge.netCombined Annotation Dependent Depletion, cadd.gs.washington.edudbNSFP, sites.google.com/site/jpopgen/dbNSFPExplicet, Genetic Power Calculator, Genetic Variant Interpretation Tool, Genome Aggregation Database, gnomad.broadinstitute.orgGenome Analysis Toolkit, gatk.broadinstitute.orgGenotype-Tissue Expression (GTEx) Portal, gtexportal.orgInterPro, Likelihood Ratio Test, MutationAssessor, mutationassessor.org/r3/MutationTaster, Online Mendelian Inheritance in Man, PolyPhen-2, genetics.bwh.harvard.edu/pph2/PROVEAN, provean.jcvi.orgsilva, Seurat, satijalab.org/seurat/UCSC Genome Browser, genome.ucsc.edu
