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Authors
Fritz, Nikola
Berens, Sabrina
Dong, Yuanjun
Martínez, Cristina
Schmitteckert, Stefanie
Houghton, Lesley A.
Goebel-Stengel, Miriam
Wahl, Verena
Kabisch, Maria
Götze, Dorothea
D’Amato, Mauro
Zheng, Tenghao
Röth, Ralph
Mönnikes, Hubert
Tesarz, Jonas
Engel, Felicitas
Gauss, Annika
Raithel, Martin
Andresen, Viola
Keller, Jutta
Frieling, Thomas
Pehl, Christian
Stein-Thöringer, Christoph
Clarke, Gerard
Kennedy, Paul J.
Cryan, John F.
Dinan, Timothy G.
Quigley, Eamonn M. M.
Spiller, Robin
Beltrán, Caroll
Madrid, Ana María
Torres, Verónica
Mayer, Emeran A.
Sayuk, Gregory
Gazouli, Maria
Karamanolis, George
Bustamante, Mariona
Estivil, Xavier
Rabionet, Raquel
Hoffmann, Per
Nöthen, Markus M.
Heilmann-Heimbach, Stefanie
Schmidt, Börge
Franke, André
Lieb, Wolfgang
Herzog, Wolfgang
Boeckxstaens, Guy
Wouters, Mira M.
Simrén, Magnus
Rappold, Gudrun A.
Vicario, Maria
Santos, Javier
Schaefert, Rainer
Lorenzo-Bermejo, Justo
Niesler, Beate https://orcid.org/0000-0001-7881-6112
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Funding
Funding for this research was provided by:
Medizinischen Fakultät Heidelberg, Universität Heidelberg
Universitätsklinikum Heidelberg
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Article History
Received: 28 June 2021
Revised: 18 July 2022
Accepted: 4 August 2022
First Online: 19 September 2022
Declarations
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: All studies were approved of by the following local ethics committees: Germany, Heidelberg: Ethical Committee, Medical Faculty of the Heidelberg University Hospital (S067/2010); Germany, Berlin: Ethical Committee Charité Berlin Campus Mitte (No Si 285); Germany, Erlangen, Ethical Committee, Medical Faculty of the University of Erlangen-Nürnberg (Ethik No. 4581); Chile, Santiago: Ethical Commitee Hospital Clínico Universidad de Chile (Acta-No25/2015, Nº27/2019); Greece, Athens: Ethical committee of the Aretaieio University Hospital, Medical School, National and Kapodistrian University of Athens (008/21–11-2017); Ireland, Cork: Clinical Research Ethics Committee (APC024); Spain, Barcelona: Ethics Committee of Hospital Universitari Vall d´Hebron (PR(AG)159/2011) and Ethics Committee of Par de Salut Mar (2005/2106/I); Sweden, Stockholm: Karolinska Institutet’s Ethics Review Board (dnr 2009/1059–31/3); Sweden, Gothenburg: Regional Ethical Review Board in Gothenburg (S489-02 and 731–09); UK, Manchester: NHS National Research Ethics Service, South Manchester Research Ethics Committee, Genetics of Functional GI Disorders (09/H1003/1); UK, Nottingham: clinical trial clinicaltrials.gov (identifier NCT00745004), approved by Nottingham Research Ethics Committee 2 (REC reference number 08/H0408/134) []; USA, St.Louis, WA: Washington University in St. Louis, Human Research Protection Office (IRB ID #: 201103220); USA, Los Angeles, CA: University of California Los Angeles, HORPP Office of the human research protection program (IRB#12–001802-CR-00004). Furthermore, a cohort of IBS patients and controls from the UK, USA, and Canada were included in this study; these were kindly provided by Glaxo Smith Kline (UK, GenIBS/2005/0000/01).
: Written informed consent was obtained from all subjects.
: The authors declare no conflict of interest.
