Pechlivanis, Sonali http://orcid.org/0000-0002-6181-7044
Schmausser-Hechfellner, Elisabeth http://orcid.org/0000-0002-2317-3313
Schaub, Bianca http://orcid.org/0000-0003-1652-8873
Skevaki, Chrysanthi http://orcid.org/0000-0001-5194-5635
Barnig, Cindy
Roduit, Caroline http://orcid.org/0000-0002-5988-0570
Divaret-Chauveau, Amandine http://orcid.org/0000-0002-2492-9864
Karvonen, Anne M. http://orcid.org/0000-0003-2257-2934
Riedler, Josef http://orcid.org/0000-0003-3029-6212
Illi, Sabina http://orcid.org/0000-0003-4994-7732
von Mutius, Erika http://orcid.org/0000-0002-8893-4515
Beerweiler, Claudia
Böck, Andreas
Renz, Harald
Foppiano, Francesco
Genuneit, Jon
Theodorou, Johanna
Depner, Martin
Ege, Markus J
Pagani, Giulia
Kabesch, Michael
Pfefferle, Petra I.
Pekkanen, Juha
Roponen, Marjut
Täubel, Martin
Kirjavainen, Pirkka V.
Frei, Remo
Lauener, Roger
Laurent, Lucie
Dalphin, Marie-Laure
,
Funding for this research was provided by:
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Article History
Received: 30 June 2023
Accepted: 30 December 2023
First Online: 21 May 2024
Declarations
:
: <b>S. Pechlivanis</b> has not received any support for this manuscript. There are no relationships, activities or interests related to the content of the manuscript. <b>E. Schmausser-Hechfellner</b> has not received any support for this manuscript. There are no relationships, activities or interests related to the content of the manuscript. <b>B. Schaub</b> has received the following support for this manuscript: DFG. <i>In the past 36 months</i>: Grants or contracts: DFG, BMBF, EU; Consulting fees: Sanofi; Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events: GlaxoSmithKline, Novartis, Sanofi; Participation on a Data Safety Monitoring Board or Advisory Board: Sanofi. <b>C. Skevaki</b> has not received any support for this manuscript. <i> In the past 36 months</i>: Grants or contracts: Universities Giessen and Marburg Lung Center (UGLMC) – Payment to institution, German Center for Lung Research (DZL) – Payment to Institution, University Hospital Giessen and Marburg (UKGM) research funding – According to article 2, section 3 cooperation agreement, Payment to Institution, Deutsche Forschungsgemeinschaft (DFG) - SFB1021 (C04)- Project-ID 197785619, KFO 309 (P10), SK 317/1-1 (Project Nr. 428518790), Payment to Institution, TransMIT - Payment to me and Institution, Mead Johnson Nutrition (MJN) – Payment to Institution; Consulting fees: Bencard Allergie – Payment to me, Thermo Fisher Scientific – Payment to me; Support for attending meetings and/or travel: Bencard Allergy – Payment to me, regarding AD. Board meetings; Participation on a Data Safety Monitoring Board or Advisory Board: Bencard Allergy – Payment to me, regarding AD. Board meetings; Leadership or fiduciary role in other board, society, committee or advocacy group, paid or unpaid: ESGREV Board Member – unpaid, DZL ALLIANCE ExCom Member – unpaid; Receipt of equipment, materials, drugs, medical writing, gifts or other services: Bencard Allergie – MCT adjuvant for animal experiments. <b>C. Barnig</b> has not received any support for this manuscript. There are no relationships, activities or interests related to the content of the manuscript. <b>C. Roduit</b> has not received any support for this manuscript. <i>In the past 36 months</i>: Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events: ALK, University Bern; Support for attending meetings and/or travel: ALK. <b>A. Divaret-Chauveau</b> has received the following support for this manuscript: Grant from Don du Souffle for the PASTURE 16-yr – University Hospital of Besançon, Grant from Fondation du Souffle for the PASTURE 16-yr visit – University Hospital of Besançon, Grant from ARAIRLOR (Association Régionale d’Aide aux Insuffisants Respiratoires de Lorraine) for the PASTURE 16-yr visit – University Hospital of Besançon; <i>In the past 36 months</i>: Grants or contracts: Contract with the French public agency ANSES as an expert in allergy and paediatric for the Human Nutrition Committee – From 2018 to 2021, Grant from Novartis for a study on the protective role of farm environment on asthma and cough – University Hospital of Besançon, Grant from ARAIRLOR (Association Régionale d’Aide aux Insuffisants Respiratoires de Lorraine) for a study on the protective role of farm environment on asthma and cough – EA3450 DevAH, University of Lorraine; Consulting fees: Expert in pediatric allergy for Sanofi, Expert in food allergy for Stallergens, Expert in pediatric allergy for ALK, Expert in food allergy for Aimmune Therapeutics (all direct payment); Payment or honoraria: Novartis (speaker at symposium at the Pulmonology and Allergy Paediatric congress in France in 2020) – Direct payment, ALK speaker at symposium at a Paediatric congress in France in 2023) – Direct payment; Support for attending meetings and/or travel: Novartis for the French congress of Allergy 2022, ALK for the Pediatric congress 2023, Novartis for the French congress of Allergy 2023, ALK for the EAACI congress 2023 (all: Support for attending meeting and travel); Stock or stock options: Essilor Luxottica. <b>A.M. Karvonen</b> has not received any support for this manuscript. <i>In the past 36 months</i>: Grants or contracts: Päivikki and Sakari Sohlberg Foundation, Academy of Finland, Juho Vainio Foundation, Yrjö Jahnsson Foundation, Kuopio Area Respiratory Foundation, The Finnish Cultural Foundation (all: Payments were made to our institution). <b>J. Riedler</b> has not received any support for this manuscript. There are no relationships, activities or interests related to the content of the manuscript. <b>S. Illi</b> has not received any support for this manuscript. There are no relationships, activities or interests related to the content of the manuscript. <b>E. von Mutius</b> has received the following support for this manuscript: PASTURE. <i>In the past 36 months</i>: Grants or contracts: German Federal Ministry of Education and Research (BMBF) German Center for Lung Research, Bavarian State Ministry of Health and Care for “URS Study”, 01/21, “Impact Chip Study“, OM Pharma S.A., Go Bio Initial Grant, BMBF (Federal Ministry of Education and Research), European Research Council award, “BEAR Study”, O.M. Pharma S.A.; Royalties or licenses: Elsevier GmbH, Georg Thieme Verlag, Springer-Verlag GmbH, Elsevier Ltd., Springer Nature Group; Consulting fees: Chinese University of Hongkong, European Commission, HiPP GmbH & Co KG, AstraZeneca, Imperial College London, OM Pharma, ALK-Abello Arzneimittel GmbH; Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events: Massachusetts Medical Society, Springer-Verlag GmbH, Elsevier Ltd., Böhringer Ingelheim International GmbH, European Respiratory Society (ERS), Universiteit Utrecht, Faculteit Diergeneeskunde, Universität Salzburg, Springer Medizin Verlag GmbH, Japanese Society of Pediatric Allergy and Clinical Immunology (JSPACI), Klinikum Rechts der Isar, University of Colorado, Paul-Martini-Stiftung, Astra Zeneca, Imperial College London, Children’s Hospital Research Institute of Manitoba, Kompetenzzentrum für Ernährung (Kern), OM Pharma S.A., Swedish Pediatric Society for Allergy and Lung Medicine, Chinese College of Allergy and Asthma (CCAA), ALK-Abello Arzneimittel GmbH, Abbott Laboratories, Deutscher Apotheker Verlag GmbH & Co. KG, Japanese Society of Allergology, British Society for Asthma and Clinical Immunology, American Academy of Allergy, Asthma & Immunology, OM Pharma S.A.; Support for attending meetings and/or travel: Verein zur Förderung der Pneumologie am Krankenhaus Großhansdorf e.V., Pneumologie Developpement, Mondial Congress & Events GmbH & Co. KG, American Academy of Allergy, Asthma & Immunology, Imperial College London, Margaux Orange, Volkswagen Stiftung, Böhringer Ingelheim International GmbH, European Respiratory Society (ERS), Universiteit Utrecht, Faculteit Diergeneeskunde, Österreichische Gesellschaft f. Allergologie u. Immunologie, Massachusetts Medical Society, OM Pharma S. A., Hanson Wade Ltd., iKOMM GmbH, DSI Dansk Borneastma Center, American Thoracic Society, HiPP GmbH & Co KG, Universiteit Utrecht, Faculteit Bètawetenschappen, ALK-Abello Arzneimittel GmbH, Deutsches Zentrum für Lungenforschung (DZL), Fabio Luigi Massimo Ricciardolo/Contatto S.r.l., Fraunhofer ITEM Hannover, MCCA Institut für Immunologie Uni Wien, Swiss Institute of Allergy and Asthma Research (SIAF) Davos (Associated Institute of the University of Zurich), MHH (Medizinische Hochschule Hannover, European Respiratory Socierty, Natasha Allergy Research Foundation, Deutsche Forschungsgemeinschaft, Gordon Research Conferences, Socieded Chilena de Enfermedades Respiratorias, Arla, Universität Leiden, American Academy of Allergy, Asthma & Clinical Immunology, Deutsche Forschungsgemeinschaft (DFG), ERS, Deutsches Zentrum für Lungenforschung; Patents planned, issued or pending: EvM has patent No. PCT/EP2019/085016 (Barn dust extract for the prevention and treatment of diseases) pending (Barn dust extract for the prevention and treatment of diseases) pending, royalties paid to ProtectImmun for patent EP2361632 (Specific environmental bacteria for the protection from and/or the treatment of allergic, chronic inflammatory and/or autoimmune disorders, granted on 19 March 2014), and patents EP1411977 (Composition containing bacterial antigens used for the prophylaxis and the treatment of allergic diseases, granted on 18 April 2007), EP1637147 (Stable dust extract for allergy protection, granted on 10 December 2008), and EP 1964570 (Pharmaceutical compound to protect against allergies and inflammatory diseases, granted on 21 November 2012) licensed to ProtectImmun. Patent EP21189353.2. 2021. von Mutius E, Rankl B, Bracher F, Müller C, Walker A, Hauck SM, Merl-Pham J, inventors; PROTEINS IDENTIFIED FROM BARN DUST EXTRACT FOR THE PREVENTION AND TREATMENT OF DISEASES. Patent CT/US2021/016918. 2021. Martinez FD, Vercelli D, Snyder SA, von Mutius E, Pivniouk V, Marques dos Santos M, inventors; THERAPEUTIC FRACTIONS AND PROTEINS FROM ASTHMA-PROTECTIVE FARM DUST. Patent EP21189353.2. 2021. von Mutius E, Rankl B, Bracher F, Müller C, Walker A, Hauck SM, Merl-Pham J, Adler H, Yildirim A.Ö., Sattler M, Santos Dias Mourao A, Borggräfe J, O’Connor P.D., Plettenburg O, inventors; PROTEINS IDENTIFIED FROM BARN DUST EXTRACT FOR THE PREVENTION AND TREATMENT OF DISEASES.; Participation on a Data Safety Monitoring Board or Advisory Board: Member of the EXPANSE (funded by European Commission) Scientific Advisory Board, Member of the BEAMS External Scientific Advisory Board (ESAB), Member of the Editorial Board of “The Journal of Allergy and Clinical Immunology: In Practice”, Member of the Scientific Advisory Board of the Children’s Respiratory and Environmental Workgroup (CREW), Member of the International Scientific & Societal Advisory Board (ISSAB) of Utrecht Life Sciences (ULS), University of Utrecht, Member of External Review Panel of the Faculty of Veterinary Science, University of Utrecht, Member of the Selection Committee for the Gottfried Wilhelm Leibniz Programme (DFG), Member of the International Advisory Board of Asthma UK Centre for Applied Research (AUKCAR), Member of the International Advisory Board of “The Lancet Respiratory Medicine”, Member of the Scientific Advisory Board of the CHILD (Canadian Healthy Infant Longitudinal Development) study, McMaster University, Hamilton, Canada, Asthma UK Centre for Applied Research, Pediatric Scientific Advisory Board Iceland, Abbott Allergy Risk Reduction Advisory Board. <b>PASTURE Study Group:</b><b> C. Beerweiler</b> has not received any support for this manuscript. <i>In the past 36 months</i>: Grants or contracts: Friedrich-Baur-Foundation Grant 2023; Support for attending meetings and/or travel: EAACI 2023 Travel Grant. <b>A. Böck</b> has not received any support for this manuscript. There are no relationships, activities or interests related to the content of the manuscript. <b>H. Renz</b> has not received any support for this manuscript. There are no relationships, activities or interests related to the content of the manuscript. <b>F. Foppiano </b>has not received any support for this manuscript. <i>In the past 36 months</i>: Support for attending meetings and/or travel: EAACI 2023 Travel Grant. <b>J. Genuneit</b> has not received any support for this manuscript. <i>In the past 36 months</i>: Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events: yearly honoraria for work as Associate Editor for the journal Pediatric Allergy and Immunology. <b>J. Theodorou</b> has not received any support for this manuscript. There are no relationships, activities or interests related to the content of the manuscript. <b>M. Depner</b> has not received any support for this manuscript. There are no relationships, activities or interests related to the content of the manuscript. <b>M.J. Ege</b> has not received any support for this manuscript. <i>In the past 36 months</i>: Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events: EAACI; Payment for expert testimony: EU, SNSF; Support for attending meetings and/or travel: ERS; Patents planned, issued or pending: EP000002361632B1, EP000001964570B1. <b>G. Pagani</b> has not received any support for this manuscript. There are no relationships, activities or interests related to the content of the manuscript. <b>M. Kabesch</b> has not received any support for this manuscript. There are no relationships, activities or interests related to the content of the manuscript. <b>P.I. Pfefferle</b> (Germany) has not received any support for this manuscript. There are no relationships, activities or interests related to the content of the manuscript. <b>J. Pekkanen</b> has not received any support for this manuscript. There are no relationships, activities or interests related to the content of the manuscript. <b>M. Roponen</b> has not received any support for this manuscript. There are no relationships, activities or interests related to the content of the manuscript. <b>M. Täubel</b> has not received any support for this manuscript. There are no relationships, activities or interests related to the content of the manuscript. <b>P.V. Kirjavainen</b> (Finland) has not received any support for this manuscript. There are no relationships, activities or interests related to the content of the manuscript. <b>R. Frei</b> has not received any support for this manuscript. There are no relationships, activities or interests related to the content of the manuscript. <b>R. Lauener</b> (Switzerland) has received the following support for this manuscript: Kühne Foundation / CK-CARE – Research Grant to institution, EU – Research Grant. <i>In the past 36 months</i>: Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events: AstraZeneca, Pfizer, ALK, Vifor, Milupa, Sanofi – Payment: None related to the content of this manuscript. <b>L. Laurent</b> has not received any support for this manuscript. There are no relationships, activities or interests related to the content of the manuscript. <b>M.-L. Dalphin</b> (France) has not received any support for this manuscript. There are no relationships, activities or interests related to the content of the manuscript.
: All procedures performed in studies involving human participants or on human tissue were in accordance with the ethical standards of the local research ethics committee and with the 1975 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the local research ethics committee, and written informed consent were obtained from children’s parents and the adolescence.