Huang, Mi
Claussnitzer, Melina
Saadat, Alham
Coral, Daniel E.
Kalamajski, Sebastian http://orcid.org/0000-0002-6600-9302
Franks, Paul W. http://orcid.org/0000-0002-0520-7604
Funding for this research was provided by:
LUDC-IRC
China Scholarship Council (201708420158)
The Hjelt Diabetes Foundation
Swedish Research Council (Distinguished Young Researcher Award in Medicine)
The Albert Påhlsson Foundation
European Commission (ERC-CoG_NASCENT-681742)
Lund University
Article History
Received: 14 December 2022
Accepted: 17 March 2023
First Online: 12 May 2023
Acknowledgements
: We thank J. Doudna (UC Berkeley, USA) for initial support with concepts relating to using CRISPR in <i>in vitro</i> studies and endorsement for the ERC grant application through which aspects of this work were funded. We also thank Y.-H. Tseng (Joslin Diabetes Centre) for supplying hWAs cells. We thank H. Mulder (Lund University Diabetes Centre) for comments and edits on the manuscript, and for the discussions. Some of the data in this work were presented as an abstract at the 57th EASD Annual Meeting of the EASD in 2021.
: All data generated in our current study are available upon reasonable request.
: Open access funding was provided by Lund University. MH was supported in part by the China Scholarship Council (201708420158) and by a Swedish Research Council award (Distinguished Young Researcher Award in Medicine; to PWF). The study was funded by the European Commission (ERC-CoG_NASCENT-681742) and Swedish Research Council (Distinguished Young Researcher Award in Medicine; to PWF) and by The Albert Påhlsson Foundation and The Hjelt Diabetes Foundation (to SK), and LUDC-IRC.
: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: MH and SK performed and analysed experiments. MH drafted the manuscript. SK and PWF conceived and directed the project, and also reviewed and revised the manuscript. MC, AS and DEC helped to design the experiments, analyse the data and revise the manuscript. All authors approved the publication of this study. SK and PWF are the guarantors of this work and, as such, had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.