Zanetti, Daniela http://orcid.org/0000-0002-1225-1021
Stell, Laurel http://orcid.org/0000-0003-2971-4317
Gustafsson, Stefan http://orcid.org/0000-0001-5894-0351
Abbasi, Fahim http://orcid.org/0000-0002-3932-8375
Tsao, Philip S. http://orcid.org/0000-0001-7274-9318
Knowles, Joshua W. http://orcid.org/0000-0003-1922-7240
Ferrannini, Ele
Kozakova, Michaela
Gastaldelli, Amalia
Coppack, Simon
Balkau, Beverley
Dekker, Jacqueline
Walker, Mark
Mari, Andrea
Tura, Andrea
Laville, Martine
Beck, Henning
Nolan, John
Bolli, Geremia
Golay, Alain
Konrad, Thomas
Nilsson, Peter
Melander, Olle
Mingrone, Geltrude
Perry, Colin
Petrie, John
Krebs, Michael
Gabriel, Rafael
Mitrakou, Asimina
Piatti, Piermarco
Lalic, Nebojsa
Laakso, Marku
Zethelius, Björn http://orcid.org/0000-0002-1738-0834
Ärnlöv, Johan http://orcid.org/0000-0002-6933-4637
Balkau, Beverley http://orcid.org/0000-0003-2021-413X
Walker, Mark http://orcid.org/0000-0002-2526-9810
Lazzeroni, Laura C. http://orcid.org/0000-0002-1846-6920
Lind, Lars http://orcid.org/0000-0003-2335-8542
Petrie, John R. http://orcid.org/0000-0002-4894-9819
Assimes, Themistocles L. http://orcid.org/0000-0003-2349-0009
,
Funding for this research was provided by:
Foundation for the National Institutes of Health (1R01DK114183)
Article History
Received: 20 June 2022
Accepted: 12 April 2023
First Online: 17 June 2023
Data availability
: Association results for all plasma proteins measured in both cohorts are provided in the InternalRef removed. Qualified researchers are welcome to submit proposals for collaborative work in either ULSAM (ExternalRef removed) or RISC (ExternalRef removed). Such collaborative work could include access to individual-level data on approval of the research proposal.
: This research was supported by a grant from the National Institutes of Health (1R01DK114183). The RISC study was supported by the EU Fifth Framework Programme (EU contract QLG1-CT-2001-01252) with additional funding from Astra Zeneca. The ULSAM study was supported by the Swedish Heart Lung Foundation and the Medical Faculty of Uppsala University, including the Uppsala University Hospital, the Swedish Medical Research Council (MFR5446), the Uppsala Geriatric Fund and the Thuréus Foundation for Geriatric Research. JWK is funded by NIH R01 DK116750, R01 DK120565, R01 DK106236, R01 DK107437, P30DK116074 and ADA 1-19-JDF-10. DZ was supported by the MSCA Postdoctoral Fellowships 2021 (HORIZON-MSCA-2021-PF-01-01). The funders of the study had no role in study design, data collection, data analysis, data interpretation or writing of the report.
: BZ, associate professor at Uppsala University, is employed as Scientific Director at the Swedish Medical Products Agency, Uppsala, Sweden. The views expressed in this paper are the personal views of the authors and not necessarily the views of the Swedish Medical Products Agency. The other authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: TLA, JWK, LCL, LL, FA and JRP conceived and designed the study. DZ, LS, SG and TLA carried out the analyses. DZ and TLA drafted the manuscript. DZ, LS, SG, LCL, LL, JRP and TLA verified the underlying data. TLA is responsible for the integrity of the work as a whole. All authors acquired and interpreted the data, critically revised the paper and had final responsibility for the decision to submit for publication.