Moulder, Robert http://orcid.org/0000-0003-4742-0566
Välikangas, Tommi http://orcid.org/0000-0002-6046-1920
Hirvonen, M. Karoliina http://orcid.org/0000-0003-1575-9725
Suomi, Tomi http://orcid.org/0000-0003-3639-979X
Brorsson, Caroline A. http://orcid.org/0000-0003-3473-1744
Lietzén, Niina http://orcid.org/0000-0002-3432-5415
Bruggraber, Sylvaine F. A. http://orcid.org/0000-0002-4844-8168
Overbergh, Lut http://orcid.org/0000-0001-7126-356X
Dunger, David B. http://orcid.org/0000-0002-2566-9304
Peakman, Mark http://orcid.org/0000-0003-3328-3513
Chmura, Piotr J. http://orcid.org/0000-0002-9371-6918
Brunak, Soren http://orcid.org/0000-0003-0316-5866
Schulte, Anke M.
Mathieu, Chantal http://orcid.org/0000-0002-4055-5233
Knip, Mikael http://orcid.org/0000-0003-0474-0033
Elo, Laura L. http://orcid.org/0000-0001-5648-4532
Lahesmaa, Riitta http://orcid.org/0000-0002-4782-9567
,
Funding for this research was provided by:
Academy of Finland (677943)
Sigrid Juséliuksen Säätiö
Juvenile Diabetes Research Foundation United Kingdom
Innovative Medicines Initiative 2 (No 115797 (INNODIA), No 945268 (INNODIA HARVEST)
European Research Council ERC (677943)
Academy of Finland (310561, 314443, 329278, 335434, 335611, 341342)
Jane ja Aatos Erkon Säätiö
European Federation of Pharmaceutical Industries and Associations
Leona M. and Harry B. Helmsley Charitable Trust
Medicinska Understödsföreningen Liv och Hälsa
Diabetestutkimussäätiö
Helsingin Yliopiston Tiedesäätiö
University of Turku (UTU) including Turku University Central Hospital
Article History
Received: 10 March 2023
Accepted: 6 June 2023
First Online: 4 August 2023
Acknowledgements
: We are grateful to the staff of the University of Cambridge Department of Paediatrics laboratory, particularly A. Qureshi, for their contributions to the management of the samples. Similarly, at Turku Bioscience, M. Hakkarainen and S. Heinonen are thanked for their excellent technical assistance, and likewise the Turku Bioscience Proteomics core facility, supported by the University of Turku, Åbo Akademi University and Biocenter Finland. The full list of INNODIA consortium members is shown below. Figure and the graphical abstract were created using BioRender.com.
: Access to these person-sensitive data is only through secure environments and by application to the INNODIA Data Access Committee.
: This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No. 115797 (INNODIA) and No. 945268 (INNODIA HARVEST). This Joint Undertaking receives support from the Union’s Horizon 2020 research and innovation programme, ‘EFPIA’, ‘JDRF’ and ‘The Leona M. and Harry B. Helmsley Charitable Trust’. RL received funding from the Academy of Finland (grants 292335, 294337, 319280, 31444, 319280, 329277, 331790), from Business Finland and by grants from JDRF, the Sigrid Jusélius Foundation, the Jane and Aatos Erkko Foundation, the Finnish Diabetes Foundation and the Finnish Cancer Foundation. LLE reports grants from the European Research Council (ERC) (677943), the Academy of Finland (310561, 314443, 329278, 335434, 335611 and 341342) and the Sigrid Jusélius Foundation during the conduct of the study. RL and MK were supported by the Academy of Finland, AoF, Centre of Excellence in Molecular Systems Immunology and Physiology Research (2012–2017, grants 250114 and 292482). MK also received support from the Sigrid Jusélius Foundation, Helsinki University Hospital Research Funds and the Liv and Hälsa Fund. Research at Turku Bioscience Centre (LLE and RL) was supported by the University of Turku Graduate School (UTUGS), Biocenter Finland, ELIXIR Finland and by the InFLAMES Flagship Programme of the Academy of Finland (decision number: 337530). TV is supported by the Doctoral Programme in Mathematics and Computer Sciences (MATTI) of the University of Turku. MKH was supported by the Turku Doctoral Programme of Molecular Medicine (TuDMM), the Finnish Cultural Foundation and the Finnish Diabetes Research Foundation.
: SB has ownerships in Intomics A/S, Hoba Therapeutics Aps, Novo Nordisk A/S, Lundbeck A/S, ALK abello A/S and managing board memberships in Proscion A/S and Intomics A/S. All other authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: RM conducted the analyses, prepared tables and figures, interpreted the data and co-wrote the manuscript. TV analysed and interpreted the data, prepared the tables and figures, and co-wrote the manuscript. MKH analysed, evaluated and interpreted the data; prepared the figures; and co-wrote the manuscript. TS supervised the analysis of the data. CAB processed and prepared the data. LO, NL and SB participated in the design of the study. DBD, MP, PJC, SB, AMS and CM initiated, designed and supervised the study. MK, LLE and RL designed and supervised the study. With the unavoidable exception of DBD (deceased), all authors edited, reviewed and approved the final version of the manuscript. RL is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
: Mathieu C, Gillard P, Casteels K, Overbergh L (KU Leuven, Belgium), Dunger D, Wallace C, Evans M, Thankamony A, Hendriks E, Bruggraber S, Qureshi A, Marcovecchio L, Paediatrics laboratory staff (University of Cambridge, UK), Peakman M, Tree T (King’s College London, UK), Morgan N, Richardson S (University of Exeter, UK), Todd J, Wicker L (University of Oxford, UK), Mander A, Dayan C, Alhadj Ali M (Cardiff University, UK), Pieber T (Medical University of Graz, Austria), Eizirik D, Cnop M (Universite Libre de Bruxelles, Belgium), Brunak S (University of Copenhagen, Denmark), Pociot F, Johannesen J, Rossing P, Legido Quigley C (Herlev University Hospital, Region Hovedstaden, Denmark), Mallone R, Scharfmann R, Boitard C (Cochin Institute Paris, France), Knip M, Otonkoski T (University of Helsinki, Finland), Veijola R (University of Oulu, Finland), Lahesmaa R, Oresic M, Toppari J (University of Turku, Finland), Danne T (Children's and Youth Hospital Hannover, Germany), Ziegler AG, Achenbach P, Rodriguez-Calvo T (Helmholtz Zentrum Muenchen, Germany), Solimena M, Bonifacio E, Speier S (TU Dresden, Germany), Holl R (University of Ulm, Germany), Dotta F (University of Siena, Italy), Chiarelli F (University of Chieti, Italy), Marchetti P (University of Pisa, Italy), Bosi E (University Vita-Salute San Raffaele, Italy), Cianfarani S, Ciampalini P (Bambino Gesù Children's Hospital, Italy), de Beaufort C (Centre Hospitalier de Luxembourg, Luxemburg), Dahl-Jørgensen K, Skrivarhaug T, Joner G, Krogvold L (Oslo University Hospital, Norway), Jarosz-Chobot P (Medical University of Silesia, Poland), Battelino T (University of Ljubljana, Slovenia), Thorens B (University of Lausanne, Switzerland), Gotthardt M (Radboud University Medical Center, the Netherlands), Roep B, Nikolic T, Zaldumbide A (Leiden University Medical Center, the Netherlands), Lernmark A, Lundgren M (Lund University, Sweden), Costecalde G (Univercell-Biosolutions, France), Strube T, Schulte A, Nitsche A, (Sanofi, Germany), Peakman M, Vela J (Sanofi, United States), von Herrath M, Wesley J, (Novo Nordisk, Denmark), Napolitano-Rosen A (GlaxoSmithKline, UK), Thomas M, Schloot N (Eli Lilly, UK), Goldfine A, Waldron-Lynch F, Kompa J, Vedala A, Hartmann N, Nicolas G (Novartis Pharma AG, Switzerland), van Rampelbergh J, Bovy N (Imcyse SA, Belgium), Dutta S, Soderberg J, Ahmed S, Martin F, Latres E (JDRF, USA), Agiostratidou G, Koralova A (The Leona M. and Harry B. Helmsley Charitable Trust, USA).
: Willemsen R (Barts Health NHS Trust, UK), Smith A (Northampton General Hospital NHS Trust, UK), Anand B (West Suffolk NHS FT, UK), Puthi V (North West Anglia NHS FT, UK), Zac-Varghese S (East & North Hertfordshire NHS Trust, UK), Datta V (Norfolk & Norwich University NHS FT, UK), Dias R (Birmingham Women’s and Children’s NHS FT, UK), Sundaram P (University Hospitals of Leicester NHS Trust, UK), Vaidya B (Royal Devon & Exeter NHS FT, UK), Patterson C (NHS Fife, UK), Owen K (Oxford University Hospitals NHS FT, UK), Dayan C (Cardiff & Vale University Health Board, UK), Piel B (Queen Elizabeth Hospital, King’s Lynn FT, UK), Heller S (Sheffield Teaching Hospitals NHS FT, UK), Randell T, Gazis T (Nottingham University Hospitals NHS Trust, UK), Bismuth Reismen E, Carel J-C (Hospital Robert Debre, France), Riveline J-P, Gautier J-F (Hospital Lariboisiere, France), Andreelli F (Hospital Lapitie-Salpetriere, France), Travert F (Hospital Bichat Claude Bernard, France), Cosson E (Hospital Jean-Verdier, France), Penfornis A, Petit C (Centre Hospitalier Sud-Francilien, France), Feve B (Hospital St Antoine, France), Lucidarme N (Hospital Jean-Verdier Pediatrie, France), Cosson E (Hospital Avicenne, France), Beressi J-P (Hospital Andre Mignot, France), Ajzenman C (Hospital Andre Mignot Pediatrie, France), Radu A (Hospital Europeen Georges-Pompidou, France), Greteau-Hamoumou S (Hospital Louis Mourier, France), Bibal C (Hospital Kremlin Bicetre, France), Meissner T (Universitatsklinikum der Heinrich-Heine-Univeritat Dusseldorf, Germany), Heidtmann B (Katholisches Kinderkrankenhaus Wilhelmstift, Germany), Toni S (AOU Meyer, Italy), Rami-Merhar B (Medical University of Vienna, Austria), Eeckhout B, Peene B, Vantongerloo N (Algemeen Ziekenhuis Geel Sint-Dimpna Geel, Belgium), Maes T, Gommers L (Imeldziekenhuis Bonheiden, Belgium).