Hughes, Alice E. http://orcid.org/0000-0003-1352-4447
Houghton, Jayne A. L. http://orcid.org/0000-0001-9474-1536
Bunce, Benjamin
Chakera, Ali J. http://orcid.org/0000-0001-5820-8363
Spyer, Gill
Shepherd, Maggie H. http://orcid.org/0000-0003-2660-0955
Flanagan, Sarah E. http://orcid.org/0000-0002-8670-6340
Hattersley, Andrew T. http://orcid.org/0000-0001-5620-473X
Funding for this research was provided by:
National Institute for Health and Care Research (NIHR4-SNMRL058)
Wellcome Trust (223187/Z/21/Z, WT203918)
NIHR Exeter Biomedical Research Centre
Article History
Received: 21 April 2023
Accepted: 8 June 2023
First Online: 31 August 2023
Acknowledgements
: We are grateful to the patients and their clinicians for their assistance with this work. We would like to thank the laboratory and biomedical scientists (Kevin Colclough, David Evans, Amy Hutchings, Natasha Philpott and Rachel Van Heughten) at the Exeter Genomics Laboratory, Royal Devon University Hospitals NHS Foundation Trust, for their technical support.
: Individual-level data used in this study are not freely available to protect the identity of research participants. Information for researchers and protocols for the study and submissions to the Genetic Beta Cell Research Bank are available online (ExternalRef removed and ExternalRef removed). Requests for additional data specifically related to this work are available to researchers through managed open collaboration. Requests will be considered after liaising with the relevant study and ethics committees, and should be made in writing to the corresponding author, AT Hattersley.
: AEH was supported by a Wellcome Trust and University of Exeter-funded GW4-Clinical Academic Training PhD Fellowship (WT203918). MHS is an NIHR senior nurse and research leader (NIHR4-SNMRL058). SEF is a Wellcome Trust Senior Research Fellow (223187/Z/21/Z). ATH is employed as a core member of staff within the NIHR Exeter Clinical Research Facility, and is a NIHR Emeritus Senior Investigator. This study was supported by the NIHR Exeter Biomedical Research Centre. The study sponsor/funder was not involved in the design of the study, the collection, analysis and interpretation of data or writing the report, and did not impose any restrictions regarding publication of the report. The views expressed in this paper are those of the authors and not necessarily those of any funder.
: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: AEH and ATH designed the study. JALH, AJC, GS and MHS collected the data. JALH, BB, SEF and ATH analysed the data. AEH wrote the first draft of the manuscript with successive drafts, receiving input from AJC, SEF and ATH. JALH, BB, AJC, GS and MHS contributed to editing the manuscript. AEH and ATH directly accessed and verified the data reported in the manuscript. All authors reviewed and approved the final manuscript for submission. ATH is the guarantor of this work.