Oostveen, Reindert F. http://orcid.org/0000-0001-7182-2886
Kaiser, Yannick http://orcid.org/0000-0001-6869-0042
Ståhle, Mia R. http://orcid.org/0000-0002-5904-1312
Nurmohamed, Nick S. http://orcid.org/0000-0001-9045-6009
Tzolos, Evangelos http://orcid.org/0000-0003-0038-043X
Dweck, Marc R. http://orcid.org/0000-0001-9847-5917
Kroon, Jeffrey http://orcid.org/0000-0001-9983-6614
Murphy, Andrew J. http://orcid.org/0000-0001-7039-7777
Dey, Damini http://orcid.org/0000-0003-2236-6970
Slomka, Piotr J. http://orcid.org/0000-0002-6110-938X
Verberne, Hein J. http://orcid.org/0000-0003-3774-2414
Stroes, Erik S. G. http://orcid.org/0000-0001-9555-6260
Hanssen, Nordin M. J. http://orcid.org/0000-0001-9541-7244
Funding for this research was provided by:
Netherlands Heart Foundation (2021T055)
Article History
Received: 21 May 2023
Accepted: 10 July 2023
First Online: 15 August 2023
Acknowledgements
: Some of the data were presented as an abstract at the European Atherosclerosis Society conference in Milan in 2022 and at the American College of Cardiology conference in New Orleans in 2023.
: The data that support the findings of this study are not openly available due to reasons of sensitivity and are available from the corresponding author upon reasonable request. Data are located in controlled access data storage at the Amsterdam UMC, location AMC.
: YK and ESGS were supported by the Netherlands Heart Foundation CVON 2017-20: generating the best evidence-based pharmaceutical targets for atherosclerosis [GENIUS II]). PJS has received funding from the National Institutes of Health. NMJH is supported by a senior clinical scientist grant from the Netherlands Heart Foundation (grant number 2021T055)
: PJS has served as a consultant to SYNEKTIK, received research funding from Siemens, has received royalties for software from Cedars-Sinai Medical Center and is associate editor for the <i>Journal of Nuclear Cardiology</i>. NMJH has received honorarium from Novo Nordisk and Boehringer Ingelheim. JK received a preclinical research grant from Oxitope Pharma B.V. NSN is cofounder of Lipid Tools. MRD has served as consultant to Edwards Lifesciences and Medtronic; received research funding from Edwards Lifesciences and Medtronic; and has received speaking fees from NVT. ESGS has received lecturing fees to his institution from Amgen, Sanofi, Esperion, Novartis, NovoNordisk and Ionis Pharmaceuticals. All other authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: RFO was involved in planning of the study, conducted the clinical experiments, assisted in imaging analyses, and was responsible for the statistical analyses, creating the figures and writing the manuscript. YK conceptualised the study, was responsible for the planning of the study, conducted the clinical experiments, and assisted in the statistical analyses and drafting the manuscript. MRS was involved in the interpretation of the imaging data and writing the manuscript. NSN was involved in planning of the study and conducting clinical experiments. ET performed the imaging analyses and assisted in drafting the manuscript and creating the figures. MRD assisted in the imaging analyses and drafting of the manuscript. JK took part in interpretation of data and conceptualising the study. AJM took part in interpretation of the data and revising the article. DD and PJS allowed access to FusionQuant for the analyses of the scans and provided crucial assistance in the imaging analyses. HJV and ESGS were responsible for conceptualising the study and were involved in planning the study, interpretation of data and writing the manuscript. NMJH assisted in interpretation of the data, writing the manuscript, and revised the article critically for important intellectual content. All authors contributed to interpretation of the data, critically reviewed and edited the manuscript and approved the version to be published. NMJH is the guarantor of this work and, as such, had full access to all the data in the study and takes full responsibility for the integrity of the data and the accuracy of the data analysis.