Hu, Xiaoli http://orcid.org/0000-0001-9770-6517
Buhl, Christian Selmer http://orcid.org/0000-0002-6610-0691
Sjogaard, Marie Balle http://orcid.org/0000-0001-9166-2795
Schousboe, Karoline http://orcid.org/0000-0003-3824-7482
Mizrak, Hatice Isik http://orcid.org/0000-0003-1218-6271
Kufaishi, Huda http://orcid.org/0000-0001-9022-0004
Jensen, Troels Staehelin http://orcid.org/0000-0002-3487-6380
Hansen, Christian Stevns http://orcid.org/0000-0002-5782-3476
Yderstræde, Knud Bonnet http://orcid.org/0000-0002-4411-3598
Zhang, Ming-Dong http://orcid.org/0000-0003-2033-3446
Ernfors, Patrik http://orcid.org/0000-0002-1140-3986
Nyengaard, Jens Randel http://orcid.org/0000-0002-8084-4646
Karlsson, Pall http://orcid.org/0000-0001-7082-9576
Funding for this research was provided by:
Lundbeckfonden (R359-2020-2620)
Novo Nordisk Foundation Center for Basic Metabolic Research (NNF17SA0031406, NNF18OC0052301)
Royal Danish Library, Aarhus University Library
Article History
Received: 31 March 2023
Accepted: 1 August 2023
First Online: 20 September 2023
Data availability
: Due to restrictions related to Danish law protecting patient privacy, the data used in this study can only be made available through an application to Aarhus University by contacting the corresponding author or Aarhus University (clin@au.dk).
: Open access funding provided by Royal Danish Library, Aarhus University Library. This research was funded by the Novo Nordisk Foundation (grant no. NNF18OC0052301) and by the Lundbeck Foundation (grant no. R359-2020-2620). XH is funded by a PhD stipend from the Danish Diabetes Academy, which is funded by the Novo Nordisk Foundation (grant no. NNF17SA0031406).
: PK has received personal fees from Grünenthal, Alnylam and Vertex Pharmaceuticals and has received a research grant from Merck outside the submitted work. The other authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: All authors meet the ICMJE uniform requirements for authorship and approved the final version of the manuscript. PK, TSJ, CSB, CSH, KBY, JRN, PE, MDZ and XH conceptualised the study and contributed to study design. XH and PK participated in skin biopsy data acquisition. XH, PK, CSB and MBS participated in data analysis. CSB, CSH, PK, KBY, KS, HIM and HK contributed to clinical data acquisition. All authors contributed to manuscript drafting, editing and revision for intellectual content. PK and XH are responsible for the integrity of the work as a whole.