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Authors
Himuro, Miwa https://orcid.org/0000-0003-1621-2844
Wakabayashi, Yuka
Taguchi, Tomomi https://orcid.org/0000-0002-9000-6910
Katahira, Takehiro
Suzuki, Luka
Iida, Hitoshi https://orcid.org/0000-0001-5889-7701
Ogihara, Takeshi
Nishida, Yuya https://orcid.org/0000-0002-8396-423X
Sasaki, Shugo https://orcid.org/0000-0002-3696-7809
Lynn, Francis C. https://orcid.org/0000-0001-9318-1063
Hiraoka, Yuichi
Oshima, Shigeru https://orcid.org/0000-0003-1186-9177
Okamoto, Ryuichi https://orcid.org/0000-0002-7047-571X
Fujitani, Yoshio https://orcid.org/0000-0003-0196-4736
Watada, Hirotaka https://orcid.org/0000-0001-5961-1816
Miyatsuka, Takeshi https://orcid.org/0000-0003-2618-3450
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Funding
Funding for this research was provided by:
Japan Diabetes Society (Junior Scientist Development Grant supported by No)
Japan Foundation for Applied Enzymology
Joint Research Program of the Institute for Molecular and Cellular Regulation, Gunma University
Japan IDDM network
Japan Society for the Promotion of Science (16K09766, 19H04060, 20K08895, 21K16345)
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Article History
Received: 28 May 2023
Accepted: 25 August 2023
First Online: 23 October 2023
Acknowledgements
: We thank H. Hibino, S. Ishikawa and S. Matsui (Juntendo University) for their excellent technical assistance in the mouse experiments. We also thank the Mouse Facility and the Cell Imaging Core, Laboratory of Molecular and Biochemical Research, and Research Support Center at Juntendo University for their support.
: Raw and processed RNA sequencing data for this study has been deposited in the Gene Expression Omnibus under accession number GSE229090.
: This work was supported by grants from the Japan Society for the Promotion of Science (JSPS) KAKENHI (No. 20K08895 to TO, 21K16345 to MH, 16K09766, 19H04060 to TM), the Japan Diabetes Society Junior Scientist Development Grant supported by Novo Nordisk Pharma Ltd. (to MH), the Japan Foundation for Applied Enzymology (to MH), Japan Insulin-Dependent Diabetes Mellitus (IDDM) Network (to TM) and the joint research programme of the Institute for Molecular and Cellular Regulation, Gunma University (no. 17002 to TM and no. 20004 to MH).
: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: TM and MH designed the whole project and wrote the manuscript. YH, SO and RO contributed to the generation of the reporter mouse line. MH, YW, TK and LS contributed to the acquisition and analysis of the data. HI, TT, TO, YN, SS, FCL, YF and HW contributed to the interpretation of the data. All authors revised the manuscript critically for important intellectual content and approved the final version of the manuscript. TM is the guarantor of this work.
