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Article History

Received: 5 June 2023

Accepted: 30 August 2023

First Online: 3 November 2023

Acknowledgements

: The authors thank all volunteers for their participation. The authors thank M. Ajie (Department of Internal Medicine, Radboudumc, Nijmegen, the Netherlands) and E. Bakker (Department of Physiology, Radboudumc, Nijmegen, the Netherlands) for their assistance with analysing CGM data and activity tracker data, respectively. The authors also thank E. J. Abbink (Department of Internal Medicine, Radboudumc, Nijmegen, the Netherlands) and L. J. Oost (Department of Physiology, Radboudumc, Nijmegen, the Netherlands) for their comments on the protocol, and E. J. Abbink and the research nurses from the Radboudumc Technology Center Department of Clinical Studies, Radboudumc, Nijmegen, the Netherlands, for assistance during the clamps. The individuals named above, and the research nurses, received no financial support for their participation. Some of the data was presented as an abstract at the EASD annual meeting in 2023.

: The datasets generated during and/or analysed in the current study are available from the corresponding author upon reasonable request.

: The study was supported by a grant from the Dutch Diabetes Research Foundation (2017–81–014). The foundation was not involved in the collection, analyses and interpretation of data, nor in writing the report and the decision to submit for publication.

: BEdG is associate editor for <i>Diabetologia</i>, but was not involved in the handling of the manuscript during the editorial process. The other authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.

: LCAD, JHFdB, CJT and BEdG designed the study. LCAD recruited the participants, performed the experiments, collected the data and wrote the first version of the manuscript. LCAD and LR performed the statistical analyses. AEvH supervised the laboratory analyses. All authors discussed the results and implications, commented on the manuscript at all stages and approved the final version of the manuscript. BEdG is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.