Paz-Barba, Miriam
Muñoz Garcia, Amadeo
de Winter, Twan J. J.
de Graaf, Natascha
van Agen, Maarten
van der Sar, Elisa
Lambregtse, Ferdy
Daleman, Lizanne
van der Slik, Arno
Zaldumbide, Arnaud
de Koning, Eelco J. P.
Carlotti, Françoise http://orcid.org/0000-0001-7929-8468
Funding for this research was provided by:
Diabetes Fonds
Stichting Diabetes Onderzoek Nederland
Bontius Stichting
Juvenile Diabetes Research Foundation International
Novo Nordisk Foundation Center for Stem Cell Medicine reNEW (NNF21CC0073729)
Article History
Received: 16 June 2023
Accepted: 22 August 2023
First Online: 4 November 2023
Acknowledgements
: The authors thank R. C. Hoeben and M. Rabelink from the viral vector facility (Dept of Cell & Chemical Biology, Leiden University Medical Center) for the production of lentiviral vectors. We also thank S. du Pré (Dept of Internal Medicine, Leiden University Medical Center) for careful reading of the manuscript.
: scRNAseq data generated by our laboratory and used in this study are available in the Gene Expression Omnibus <b>(</b>GEO; ExternalRef removed), accession number GSE218316.
: FC and EJPdK have received funding from the DON Foundation, the Dutch Diabetes Research Foundation, JDRF, the Bontius Foundation and the Novo Nordisk Foundation Center for Stem Cell Medicine reNEW (NNF21CC0073729).
: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: MP-B and FC designed experiments and wrote and revised the manuscript. FC and EJPdK received the funding and contributed to the interpretation of the results. MP-B performed experiments and the analysis and interpretation of the results. AMG and TJJdW performed the RNA-sequencing analysis. NdG, MvA, LD, EvdS, FL and AvdS contributed to performing experiments. AZ contributed to the cloning and generation of lentiviral vectors and to the data interpretation. All authors reviewed the article and approved the final version of the manuscript. FC is the guarantor of this work.