Heianza, Yoriko http://orcid.org/0000-0002-0957-9309
Zhou, Tao http://orcid.org/0009-0008-2933-7033
Wang, Xuan
Furtado, Jeremy D. http://orcid.org/0000-0002-5258-1869
Appel, Lawrence J. http://orcid.org/0000-0002-0673-6823
Sacks, Frank M. http://orcid.org/0000-0003-1341-1995
Funding for this research was provided by:
National Institute of Diabetes and Digestive and Kidney Diseases (DK091718, DK100383, DK115679)
National Heart, Lung, and Blood Institute (R01HL084568)
National Institute of General Medical Sciences (2P20GM109036-06A1, Sub-Project ID 7233)
Tulane University (Tulane Research Centers of Excellence Awards)
Article History
Received: 28 April 2023
Accepted: 2 November 2023
First Online: 5 December 2023
Acknowledgements
: We appreciate all the participants and researchers of the OmniCarb trial for their contributions. We also thank the Translational Genomics Core of Partners HealthCare Personalized Medicine team (Cambridge, MA, USA) for their contributions in genotyping and imputation.
: Data described in the manuscript, code book and analytic code will be available from the corresponding author upon reasonable request. All data supporting the findings of this study are available within the paper and its InternalRef removed.
: The OmniCarb trial was supported by an investigator-initiated grant from the National Heart, Lung, and Blood Institute (R01HL084568). The study is supported by the National Institute of Diabetes and Digestive and Kidney Diseases (DK091718, DK100383, DK115679), and National Institute of General Medical Sciences (2P20GM109036-06A1, Sub-Project ID 7233), and the Tulane Research Centers of Excellence Awards. The sponsors had no role in the design or conduct of the present study.
: JDF was employed at the Harvard T.H. Chan School of Public Health when the study was conducted and is now an employee of and stockholder in Biogen. All other authors declare that there are no relationships or activities that might bias, or be perceived to bias, their contribution to this manuscript.
: YH contributed to the study concept, statistical analysis and interpretation of data, drafting and revising the manuscript, and study supervision. TZ and XW contributed to the analysis and interpretation of data, and drafting and revising the manuscript. JDF contributed to measurements, interpretation of data and revising the manuscript. LJA and FMS contributed to the trial design, acquisition of data, interpretation of data, revising the manuscript and funding. LQ contributed to the study concept, data acquisition, analysis and interpretation, drafting and revising the manuscript, funding and study supervision. All authors contributed to the manuscript and approved the final version and have access to all data in the present study. The corresponding authors YH and LQ take responsibility for the integrity of the data of the work as a whole.