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Article History

Received: 25 July 2023

Accepted: 13 November 2023

First Online: 11 January 2024

Acknowledgements

: The authors thank the Icahn School of Medicine at Mount Sinai Microscopy Core, the Biorepository and Pathology core and the Einstein/Sinai Diabetes Research Center Human Islet and Adenovirus Core P30DK020541 (AGO and DKS). The authors thank the Developmental Studies Hybridoma Bank, Department of Biology, The University of Iowa (Iowa City, IA, USA), for providing the human insulin antibody. The human pancreatic sections were generously provided by A. C. Powers and M. Brissova from the Vanderbilt Pancreas Biorepository, which was created with the support of NIH DK106755, DK120456, DK108120 and DK104211, The Leona M. and Harry B. Helmsley Charitable Trust and as part of efforts in the Vanderbilt Diabetes Research and Training Center (DK020593). This study used paediatric pancreas samples from the Human Atlas of the Neonatal Development and Early Life Pancreas and associated Immune Organs, a project supported by The Leona M. and Harry B. Helmsley Charitable Trust.

: The mouse lines generated in this study are available from the corresponding author upon reasonable request. The sequencing data included in this publication have been deposited in NCBI’s Gene Expression Omnibus [ ] and are accessible through GEO Series accession number GSE242718.

: This study was supported by National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Mentored Research Scientist Development Award K01 DK128387-01A1 (to SBA), the Mindich Child Health and Development Institute Pilot and Feasibility Grant (to SBA), R01DK114338 and R01DK130300 (to DKS).

: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.

: SBA, AGO, DKS developed the concept and designed the experiments. SBA, LL, LSK, IT and FH conducted experiments, collected data and analysed the data. SBA drafted the manuscript. SBA, DKS, AGO, LSK, LL, IT and FH contributed to interpretation of data and critically revised the manuscript. DKS and AGO supervised the project. All authors gave their approval of the version to be published. SBA is the guarantor of this work and takes full responsibility for the content of the manuscript.

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