Liu, Beibei
Xie, Di
Huang, Xinmei
Jin, Sungho
Dai, Yangyang
Sun, Xiaoli
Li, Da
Bennett, Anton M.
Diano, Sabrina
Huang, Yingqun http://orcid.org/0000-0002-0663-8465
Funding for this research was provided by:
Division of Diabetes, Endocrinology, and Metabolic Diseases (R01 DK124321)
Article History
Received: 29 August 2023
Accepted: 17 November 2023
First Online: 13 January 2024
Acknowledgements
: We thank A. Rao from La Jolla Institute for Immunology for the gift of <i>Tet3</i><sup>fl/fl</sup> mice, M. Zhong from Yale Stem Cell Center Genomics Core for assistance with RNA sequencing, and R. Cardone at the Yale IOMIC for mitochondrial function analyses (Seahorse) of human and mouse myotubes.
: Sequences are available from the Gene Expression Omnibus with accession number of GSE224042. All other study data are included in the article and/or InternalRef removed.
: This work was supported by a grant from the National Institute of Health (R01 DK124321 to YH). The study funder was not involved in the design of the research; the collection, analysis and interpretation of data; writing the report; and did not impose any restrictions regarding the publication of the report.
: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: YH conceived and directed the studies and wrote the manuscript. BL, DX, XH and YD performed the experiments, analysed the data and helped with manuscript preparation. SJ and SD designed and performed the hyperinsulinaemic–euglycaemic clamp studies, performed data analyses and critically reviewed the manuscript. XS and DL carried out bioinformatic analyses and critically reviewed the manuscript. AMB provided the phospho-specific antibodies to Ser265 and Thr298 of PGC-1α, performed data interpretation and critically read the manuscript. All authors have read and approved the final version of the manuscript. YH is responsible for the integrity of the work as a whole.