Rauscher, Franziska G.
Elze, Tobias
Francke, Mike
Martinez-Perez, M. Elena
Li, Yangjiani
Wirkner, Kerstin
Tönjes, Anke
Engel, Christoph
Thiery, Joachim
Blüher, Matthias
Stumvoll, Michael
Kirsten, Toralf
Loeffler, Markus
Ebert, Thomas http://orcid.org/0000-0003-1683-9276
Wang, Mengyu
Funding for this research was provided by:
Karolinska Institutet (Karolinska Institutet Research Foundation grant)
Njurfonden
European Regional Development Fund
Lions Foundation
Novo Nordisk (Novo Nordisk postdoctoral fellowship run in partne)
European Social Fund Plus
Stiftelsen Stig och Gunborg Westman
Deutsche Diabetes Gesellschaft
Otsuka Pharmaceutical (Team Award Nephrology+ 2023)
Free State Saxony
Alice Adler Fellowship
BrightFocus Foundation
Deutsche Forschungsgemeinschaft (497989466, Projektnummer 209933838 – SFB 1052/3)
Research to Prevent Blindness
Grimshaw-Gudewicz Foundation
European Foundation for the Study of Diabetes (EFSD Mentorship Programme supported by AstraZeneca)
National Institutes of Health (K99EY028631, NEI Core Grant P30EYE003790, R01EY030575, R21EY030142, R21EY030631)
Article History
Received: 25 May 2023
Accepted: 8 November 2023
First Online: 2 March 2024
Acknowledgements
: The authors wish to thank the LIFE-Adult-Study participants for their time, and we gratefully acknowledge the LIFE-Adult-Study team for their commitment to the eye investigation and corresponding exams to make this analysis possible. The authors would like to express their sincere thanks to M. Eberl (Leipzig Research Centre for Civilization Diseases (LIFE), Leipzig University, Leipzig, Germany) for data management and for obtaining the combined parameters to make this analysis possible.Some of the data were presented as an abstract at the EASD annual meeting in 2023.
: Raw data cannot be shared publicly because of consent restrictions of LIFE-Adult-Study participants. Data are available after an approved project agreement from the LIFE Leipzig Research Center for Civilization Diseases. Please contact M. Nüchter (Head of Managing Office, contact via matthias.nuechter@life.uni-leipzig.de) for data access requests.
: Open Access funding enabled and organized by Projekt DEAL. This research was supported by LIFE Leipzig Research Center for Civilization Diseases, Leipzig University (LIFE is funded by the EU, the European Social Fund, the European Regional Development Fund, and Free State Saxony’s excellence initiative; project numbers: 713-241202, 14505/2470, 14575/2470); Lions Foundation; Grimshaw-Gudewicz Foundation; Research to Prevent Blindness; BrightFocus Foundation; Alice Adler Fellowship; NIH K99EY028631 to MW; NEI Core Grant P30EYE003790; NIH R21EY030142; R21EY030631; R01EY030575; German Research Foundation (grant number DFG 497989466) to FGR. This work was further funded by the German Research Foundation (DFG) – through SFB 1052, project number 209933838, subproject C06 (AT), A01 (MS), B01 (MB). ThE was supported by a Novo Nordisk postdoctoral fellowship run in partnership with Karolinska Institutet, Stockholm, Sweden, a Karolinska Institutet Research Foundation grant, the Stiftelsen Stig och Gunborg Westman, the Swedish Kidney Foundation (Njurfonden), the German Diabetes Association (DDG), as well as by the Team Award Nephrology+ 2023 by Otsuka Pharma. ThE was further funded through the European Foundation for the Study of Diabetes Mentorship Programme supported by AstraZeneca. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: All authors met the ICMJE’s uniform authorship credit requirements. FGR, MW, TE and ThE designed the study, performed the data analysis and wrote the manuscript. YL performed the data analysis and contributed to the interpretation of the data. MF, MEM-P, KW, AT, CE, JT, MB, MS, TK and ML contributed to the interpretation of the data. All authors reviewed and edited the manuscript. All authors approved the final version of the manuscript. FGR, MW, TE and ThE are the guarantors of this work and, as such, had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.