Su, Mengqi
Hou, Yilin
Cai, Sidong
Li, Wenpeng
Wei, Yinxia
Wang, Run
Wu, Min
Liu, Mingya
Chang, Junlei
Yang, Kelaier
Yiu, Kaihang
Chen, Cong http://orcid.org/0000-0001-9076-3148
Funding for this research was provided by:
National Nature Scientific Foundation of China (No.82270400, No.82300457)
Shenzhen City Nature Scientific Foundation (No.YCYJ20220530142410023)
Guangdong Province Nature Scientific Foundation (No.2022A1515110881, No.2023A1515010731)
Shenzhen City Technology Innovation Talents Development (No.RCBS20221008093335085, No.RCBS20221008093102010)
Article History
Received: 18 October 2023
Accepted: 4 January 2024
First Online: 27 February 2024
Acknowledgements
: We extend our gratitude to Q. Lai, Assistant Researcher in the Department of Cardiology at the University of Hong Kong-Shenzhen Hospital, for her diligent contribution in participant data entry. We also thank H. Sun from the Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong for his valuable insights into experimental design and manuscript preparation.
: The proteomic data of left ventricular myocardial tissue from individuals with type 2 diabetes, encompassing both those with and without HFpEF, is available from the ProteomeXchange database at ExternalRef removed. For individual participant data related to this study, availability will commence 12 to 36 months after publication. Researchers interested in these data are invited to submit their research proposals to the corresponding author, Cong Chen, at chenc6@hku-szh.org.
: This project was supported by grants from National Nature Scientific Foundation of China (no. 82270400, no. 82300457), Guangdong Province Nature Scientific Foundation (no. 2022A1515110881, no. 2023A1515010731), Shenzhen City Nature Scientific Foundation (no. YCYJ20220530142410023) and Shenzhen City Technology Innovation Talents Development Program (no. RCBS20221008093335085, no. RCBS20221008093102010).
: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: MQS, CC and KHY were responsible for designing the study and writing the initial draft of the manuscript. RW, MW and MYL played a key role in recruiting participants. SDC, WPL and YXW carried out the experiments and collected data. YLH and KLEY were in charge of performing the statistical analyses. JLC supervised the laboratory analyses. All authors actively participated in discussing the results and implications, and provided comments at all stages of the manuscript development. They all approved the final version of the manuscript. CC and KHY, as the guarantors of the work, had full access to all data in the study and take responsibility for the integrity and accuracy of the data analysis.