Jevon, Dillon
Cottle, Louise
Hallahan, Nicole
Harwood, Richard
Samra, Jaswinder S.
Gill, Anthony J.
Loudovaris, Thomas
Thomas, Helen E.
Thorn, Peter
Funding for this research was provided by:
National Health and Medical Research Council (APP1146788)
Diabetes Australia (DART Y18G_THOP)
University of Sydney
Article History
Received: 11 January 2024
Accepted: 26 March 2024
First Online: 30 May 2024
Acknowledgements
: We thank all organ donors, participants and their families for their generosity and for enabling this work. We also thank the staff of St Vincent’s Institute involved in the islet isolation programme and Donatelife for obtaining research consent and providing the human pancreases. Some samples used in the work were obtained through the Network for Pancreatic Organ donors with Diabetes (nPOD). This research was performed with the support of nPOD (RRID:SCR_014641), a collaborative type 1 diabetes research project sponsored by JDRF (nPOD: 5-SRA-2018-557-Q-R) and The Leona M. & Harry B. Helmsley Charitable Trust (grant no. 2018PG-T1D053). The content and views expressed are the responsibility of the authors and do not necessarily reflect the official view of nPOD. Organ Procurement Organisations (OPOs) partnering with nPOD to provide research resources are listed at . Imaging was performed in the Centre for Microscopy and Microanalysis at the University of Sydney, and we thank the staff for their support of this project. We thank C. Ludick and K. Sun (University of Sydney) for input into the analysis of data. We thank the electron microscopy team of R. Parton, Robyn Webb and Richard Webb (University of Queensland) for the acquisition of the original data used in Fig. .
: All data generated or analysed during this study are included in the article. No additional resources were generated or analysed during the current study.
: Open Access funding enabled and organized by CAUL and its Member Institutions. This project was funded by the NHMRC (grant no. APP1146788 to PT and JSS, grant no. APP1128273 to PT) and Diabetes Australia (grant no. DART Y18G_THOP to PT).
: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: DJ and LC made substantial contributions to conception and design, acquisition of data, analysis and interpretation of data. NH made substantial contributions to the experimental design and the acquisition of data. JSS, AJG, TL, HET and RH all made contributions to the conception of the project and acquisition of material and data. PT made substantial contributions to conception and design, analysis and interpretation of data. All authors contributed to drafting the article or revising it critically for important intellectual content and have given final approval of the version to be published. PT is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.