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Article History

Received: 29 October 2023

Accepted: 25 March 2024

First Online: 31 May 2024

Acknowledgements

: We thank the following people for their assistance: F. Hiroto and K. Nanjo (Wakayama University of Medical Science, Japan.); S. Chen, K. Xiang and W. Jia (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine); and S. Zhan, and Y. Huang (Chinese Academy of Sciences). We apologise to authors whose works could not be cited due to space limitations.

: All data generated or analysed during this study are included in this published article (and its supplementary information files).

: The study is supported by the National Natural Science Foundation of China (grant nos 81970686, 81770791, 81471012, 81270876, 82070823) and the Interdisciplinary Program of Shanghai Jiao Tong University (grant no. YG2019ZDA08).

: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.

: LmL conceived and designed the research. JZ, RZ, CwL, XxG, YW and FsJ performed the cell experiments and acquired data. YW and YtC performed the animal experiments and acquired data. LmL, YW, YjL, LgZ, TtL, QhZ, YyJ, YtC and ML analysed data. LmL, YjL and JZ wrote the paper. YzW and MsJ conducted the statistical analysis and revised the paper for important intellectual content. All the authors reviewed the article and approved its final version. LmL is the guarantor of this work, have full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

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