Wu, Meiyan http://orcid.org/0000-0001-7679-7093
Yoon, Chang-Yun
Park, Jimin
Kim, Gyuri
Nam, Bo Young
Kim, Seonghun http://orcid.org/0000-0003-3338-1156
Park, Jung Tak http://orcid.org/0000-0002-2325-8982
Han, Seung Hyeok http://orcid.org/0000-0001-7923-5635
Kang, Shin-Wook
Yoo, Tae-Hyun http://orcid.org/0000-0002-9183-4507
Funding for this research was provided by:
Postdoctoral Science Foundation of China (2021M691212)
the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (H14C2003000016)
National Research Foundation of Korea (NRF-2019R1A6A3A13094020)
National Natural Science Foundation of China (82000689)
Natural Science Foundation of Jilin Province, China (20210101455JC)
Article History
Received: 24 May 2023
Accepted: 25 January 2024
First Online: 15 June 2024
Acknowledgements
: We especially thank S. W. Park (Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine, Seoul, South Korea) for providing experimental mice. Some of the results presented in the current article were included in the PhD thesis by Jimin Park. The graphical abstract was created using scidraw.io.
: The data supporting the findings of the present study are available from the corresponding author upon reasonable request.
: This work was supported by grants from the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (H14C2003000016), the National Research Foundation of Korea (NRF-2019R1A6A3A13094020), the National Natural Science Foundation of China (82000689), the Postdoctoral Science Foundation of China (2021M691212) and the Natural Science Foundation of Jilin Province, China (20210101455JC).
: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: T-HY conceived and supervised the project and designed the experiments. MW and C-YY performed all experiments. JP, GK and BYN performed sample preparation for TEM, image acquisition and data analysis. SK conducted BODIPY 493/503 staining and subsequent image analysis. MW and C-YY interpreted data. T-HY, C-YY and MW wrote the manuscript. JTP, SHH and S-WK reviewed the article critically for important intellectual content. All authors contributed to the analysis and discussion of the data. All authors revised and approved the manuscript in its final form. T-HY is the guarantor of this work.