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Authors
Vatanen, Tommi https://orcid.org/0000-0003-0949-1291
de Beaufort, Carine https://orcid.org/0000-0003-4310-6799
Marcovecchio, M. Loredana https://orcid.org/0000-0002-4415-316X
Overbergh, Lut https://orcid.org/0000-0001-7126-356X
Brunak, Soren https://orcid.org/0000-0003-0316-5866
Peakman, Mark https://orcid.org/0000-0003-3328-3513
Mathieu, Chantal https://orcid.org/0000-0002-4055-5233
Knip, Mikael https://orcid.org/0000-0003-0474-0033
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Funding
Funding for this research was provided by:
Juvenile Diabetes Research Foundation International
European Commission (Innovative Medicines Initiative 2 Joint Undertakin)
Leona M. and Harry B. Helmsley Charitable Trust.
University of Helsinki
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Article History
Received: 22 December 2023
Accepted: 23 April 2024
First Online: 4 June 2024
Acknowledgements
: We gratefully acknowledge all participants of the INNODIA Natural History Study which built the basis for the work presented here. Without the outstanding engagement of the people with type 1 diabetes and their relatives participating in the INNODIA clinical efforts, these data and new knowledge gains would not have been possible. The authors also want to thank all the clinical personnel for their dedication in the participant recruitment, characterisation, sample collection and preparation that were at the basis of this analysis.
: The data generated and analysed are person-sensitive and can be accessed in secure environments only. Access can be provided by application to the INNODIA Data Access Committee.
: This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreements No. 115797 (INNODIA) and No. 945268 (INNODIA HARVEST). This Joint Undertaking receives support from the Union’s Horizon 2020 research and innovation programme, the EFPIA, JDRF and the Leona M. and Harry B. Helmsley Charitable Trust.
: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: TV performed data analysis and interpretation. TV and MK drafted the manuscript. CdB, SB, MP, CM and MK and the INNODIA consortia designed the INNODIA microbiome study. MLM and LO contributed to the acquisition and interpretation of data. All authors critically reviewed and commented on the manuscript and approved the final version of the manuscript. TV and MK are responsible for the integrity of the work as a whole.
