Wreven, Elise
Ruiz de Adana, María Soledad http://orcid.org/0000-0002-7286-6853
Hardivillé, Stéphan http://orcid.org/0000-0002-3554-277X
Gmyr, Valery http://orcid.org/0000-0003-1236-359X
Kerr-Conte, Julie http://orcid.org/0000-0002-7590-1896
Chetboun, Mikael http://orcid.org/0000-0001-9870-4310
Pasquetti, Gianni
Delalleau, Nathalie
Thévenet, Julien http://orcid.org/0000-0001-6873-8640
Coddeville, Anaïs
Vallejo Herrera, María José http://orcid.org/0000-0001-7540-3320
Hinden, Liad http://orcid.org/0000-0002-0307-4350
Benavides Espínola, Inmaculada Concepción http://orcid.org/0000-0003-3058-509X
Gómez Duro, Mireia
Sanchez Salido, Lourdes http://orcid.org/0000-0002-0582-0513
Linares, Francisca http://orcid.org/0000-0001-8540-7982
Bermúdez-Silva, Francisco-Javier http://orcid.org/0000-0003-3133-9691
Tam, Joseph http://orcid.org/0000-0002-0948-0093
Bonner, Caroline http://orcid.org/0000-0002-4430-8280
Egan, Josephine M. http://orcid.org/0000-0002-8945-0053
Olveira, Gabriel http://orcid.org/0000-0002-7646-2899
Colomo, Natalia http://orcid.org/0000-0002-3259-3336
Pattou, François http://orcid.org/0000-0001-8388-3766
González-Mariscal, Isabel http://orcid.org/0000-0003-1186-1212
Funding for this research was provided by:
Agence Nationale de la Recherche (ANR-10-LABX-0046)
Consejeria de Salud y Familias, Junta de Andalucia (C-0070-2012, C1-0018-2019, PI-0318-2018)
Sociedad Española de Diabetes (CPC22133)
Institut National de la Santé et de la Recherche Médicale
Ministerio de Ciencia e Innovación (PID2021-128926OA-I0)
Article History
Received: 1 March 2024
Accepted: 22 April 2024
First Online: 12 June 2024
Acknowledgements
: Some of the data were presented as an abstract at the 32nd Annual Symposium of the International Cannabinoid Research Society in 2022. Some of the figures were created using Servier Medical Art templates. We thank the Diabetes Unit of the Regional University Hospital of Malaga and the Endocrinology, Diabetes, Obesity, and Nutrition team at IBIMA-Plataforma BIONAND SSPA (Spain) (G. Rojo, R. El Bekay, S. Garcia Serrano, E. Garcia Escobar, A. Lago, C. Maldonado, A. Gentile, S. Hamyani, Juan M. Gomez Zumaquero) for their constant support and valuable input. We thank T. Diaz Cordoba, coordinator of the Andalusian Health System Biobank at IBIMA-Plataforma BIONAND (Spain) for her constant help. We thank the Biotherapy Platform at CHU of Lille (France) for the isolation of the islets from cadaveric donors used in this study and for their contribution to the evaluation of the islets. We thank B. Legendre at UMR1190, Inserm (France) and L. Antelo, M. J. Palomo and I. Mena at IBIMA-Plataforma BIONAND (Spain) for their support in the legal framework and management of the study. We thank the team at the animal facility of the University of Malaga (Spain), for contributing to the welfare of the animals used in this study.
: Transcriptomic analysis of sorted human beta cells are available at Gene Expression Omnibus database, accession no. GSE121863, available at . The data from the study in humans are not openly available due to reasons of sensitivity and are available from the corresponding author upon reasonable request. Data are located in controlled access data storage at IBIMA-Plataforma BIONAND and Inserm UMR1190, CHU of Lille.
: This study was funded by the Consejeria de Salud y Familias of Andalucía (PI-0318-2018), the Ministry of Science and Innovation (PID2021-128926OA-I00), the Spanish Diabetes Society (Sociedad Espanola de Diabetes, SED; CPC22133) and Agence Nationale de la Recherche (Laboratoire d’excellence European Genomic Institute for Diabetes under grant ANR-10-LABX-0046). IG-M and F-JB-S were funded by the Junta de Andalucía (Nicolas Monardes program; C1-0018-2019 and C-0070-2012, respectively). CIBERDEM is an initiative of the Instituto de Salud Carlos III, Madrid, Spain. JME was supported by the Intramural Research Program of the National Institute on Aging/NIH. IG-M was supported by Inserm.
: A patent application based on this work has been filed. IG-M, F-JB-S and MSRdA are the inventors of this patent. The other authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: IG-M conceptualised and supervised the study and obtained funding. JME contributed to the conceptualisation of the study. EW, SH, VG, AC, MGD, LSS and IG-M performed experiments, and acquired, analysed and interpreted data. MSRdA, ICBE, MJVH, FL, F-JB-S, GO and NC acquired and/or analysed and/or interpreted data related to the clinical study. MC, GP, ND, JTh, CB, JK-C and FP acquired and/or analysed and/or interpreted data related to the human ex vivo study. SH contributed to the design and construction of CRISPR/Cas9 and AAVs, and LH and JTa acquired and/or analysed and/or interpreted data related to the lipidomic study. IG-M and EW performed the formal analysis. IG-M wrote the manuscript. All authors reviewed the article critically and approved the final manuscript. IG-M is the guarantor of this work.