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Authors
Davidson, Rebecca K.
Wu, Wenting
Kanojia, Sukrati
George, Rajani M.
Huter, Kayla
Sandoval, Kassandra
Osmulski, Meredith
Casey, Nolan
Spaeth, Jason M.
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Funding
Funding for this research was provided by:
Division of Cancer Prevention, National Cancer Institute (CA082709)
Division of Diabetes, Endocrinology, and Metabolic Diseases (DK097512, DK097771, DK106846, DK115633, DK127129, DK128918, DK129287)
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Article History
Received: 12 December 2023
Accepted: 16 May 2024
First Online: 3 July 2024
Acknowledgements
: NEUROG3 antibodies were kindly gifted from M. Sander (Max Delbrück Center) and UCN3 antibodies provided by P. Sawchenko (Salk Institute for Biological Studies). The authors want to thank the Indiana University Melvin and Bren Simon Cancer Center Flow Cytometry Resource Facility (funded by National Cancer Institute grant P30-CA082709, NIDDK grant U54-DK106846), the Center for Medical Genomics (supported by the Indiana University Grand Challenges Precision Health Initiative) and the Islet and Physiology and Translation Cores of the Indiana Diabetes Research Center (P30-DK097512) for their outstanding technical support.
: Raw and processed data for scRNA-seq have been deposited into the NCBI Gene Expression Omnibus (GEO) database under the accession number GSE248369.
: This work was supported by grants from the National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (K01-DK115633, R03-DK127129 and R01-DK129287 to JMS, F31-DK128918 to RKD) and by a Biomedical Research Grant award from the Indiana University School of Medicine. WW is supported by grant number U24-DK097771 from the NIDDK Information Network's (dkNET) New Investigator Pilot Program in Bioinformatics. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Indiana University School of Medicine.
: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: RKD and JMS designed the study and drafted the manuscript. RKD, WW, SK, RMG, KS, MO, KH, NC and JMS executed the experiments, and critically reviewed the manuscript. RKD and JMS performed data analysis. WW performed bioinformatics analysis. All authors reviewed and approved the final manuscript. JMS is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
