Grenko, Caleb M. http://orcid.org/0000-0002-3926-5503
Taylor, Henry J. http://orcid.org/0000-0003-2088-5240
Bonnycastle, Lori L. http://orcid.org/0000-0003-0663-3944
Xue, Dongxiang http://orcid.org/0000-0001-9654-6347
Lee, Brian N. http://orcid.org/0000-0002-6090-4306
Weiss, Zoe
Yan, Tingfen
Swift, Amy J.
Mansell, Erin C. http://orcid.org/0009-0007-9588-8338
Lee, Angela http://orcid.org/0009-0001-3730-6391
Robertson, Catherine C. http://orcid.org/0000-0002-1120-1786
Narisu, Narisu http://orcid.org/0000-0002-8483-1156
Erdos, Michael R. http://orcid.org/0000-0002-6603-1833
Chen, Shuibing http://orcid.org/0000-0002-6294-5187
Collins, Francis S. http://orcid.org/0000-0002-1023-7410
Taylor, D. Leland http://orcid.org/0000-0001-6498-6970
Funding for this research was provided by:
Gates Cambridge Trust
American Diabetes Association (9-22-PDFPM-06)
National Institute of Diabetes and Digestive and Kidney Diseases (1U01DK127777-01, R01 DK116075-01A1, R01 DK119667-01A1, R01 DK124463)
National Institutes of Health (ZIA-HG000024)
Article History
Received: 4 March 2024
Accepted: 8 May 2024
First Online: 5 July 2024
Acknowledgements
: We thank C. Krilow (TileDB, USA) for supporting early parts of the work presented in this study and thank B. Chernokal and V. Guo (Department of Surgery and Center for Genomic Health, Weill Cornell Medicine, USA) for their exceptional assistance in the molecular cloning work. We would also like to thank the NIH NIAMS Genomic Technology Section (Bethesda, MD, USA) for sequencing support.
: The scRNA-seq data from the 24 h glucose exposure experiment performed in this study are available in the database of Genotypes and Phenotypes (dbGap; ) with accession no. phs001188.v3.p1. Study metadata and summary statistics for the differential expression, gene set enrichment and candidate effector gene prediction analyses are available in the Zenodo data repository () under accession number 11123248. The code used in this study is publicly available at .
: This research was supported in part by the US National Institutes of Health grant ZIA-HG000024 (to FSC), NIDDK grants R01 DK124463, R01 DK116075-01A1, R01 DK119667-01A1 and 1U01DK127777-01 (to SC), the American Diabetes Association grant 9-22-PDFPM-06 (to DX), the Gates Cambridge Trust (to HJT) and the NIH Oxford-Cambridge scholars’ programme (to HJT). In addition, HJT is supported by core funding from the British Heart Foundation (RG/18/13/33946: RG/F/23/110103), NIHR Cambridge Biomedical Research Centre (NIHR203312), Cambridge BHF Centre of Research Excellence (RE/18/1/34212), BHF Chair Award (CH/12/2/29428) and by Health Data Research UK, which is funded by the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Department of Health and Social Care (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), Public Health Agency (Northern Ireland), British Heart Foundation and Wellcome. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care.
: SC is the co-founder of Oncobeat, Inc and iOrganBio, Inc. The remaining authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: CMG, HJT, LLB, MRE, FSC and DLT designed the research. CMG, HJT, LLB, DX, AJS, CCR, MRE, SC, FSC and DLT performed research. CMG, HJT, BNL, DX, ZW, TY, ECM, AL, NN, SC and DLT analysed data. FSC and DLT supervised the study. CMG, HJT, LLB, FSC and DLT wrote the paper. All authors reviewed and approved the paper. FSC and DLT are the guarantors of this work.