Vernstrøm, Liv http://orcid.org/0000-0003-2875-435X
Gullaksen, Søren http://orcid.org/0000-0001-8275-1278
Sørensen, Steffen S.
Ringgaard, Steffen http://orcid.org/0000-0001-5353-7379
Laustsen, Christoffer http://orcid.org/0000-0002-0317-2911
Birn, Henrik http://orcid.org/0000-0003-3715-7266
Funck, Kristian L. http://orcid.org/0000-0003-0213-5550
Laugesen, Esben http://orcid.org/0000-0003-1782-1596
Poulsen, Per L. http://orcid.org/0000-0001-6468-2715
Funding for this research was provided by:
Lægeforeningen (2019-3780/41)
Novo Nordisk Fonden (NNF170C0029064)
Health Research Fund of Central Denmark Region (A3192)
Sundhedsvidenskabelige Fakultet, Aarhus Universitet
Aarhus Universitet
Article History
Received: 28 February 2024
Accepted: 7 May 2024
First Online: 30 July 2024
Acknowledgements
: The authors thank all study participants and the laboratory technicians L. Kvist, E. Schriver, H. Petersen, L. Pedersen and P. Hornbek from the Medical Research Laboratory at the Department of Endocrinology and Internal Medicine, Aarhus University Hospital (Aarhus, Denmark). B. Bibby (Biostatistical Advisory Service, Aarhus University, Denmark) is acknowledged for invaluable statistical assistance in building the mixed model.
: The datasets generated during the current study are not publicly available because of the risk of patient re-identification and them containing information that could compromise research participants’ privacy. Interested parties can request access to de-identified data or anonymised study reports by submitting a request to the corresponding author, provided that the necessary data protection agency and ethical committee approvals are given, in compliance with relevant legislation.
: Open access funding provided by Aarhus Universitet. The work was supported by research grants from the Novo Nordisk Foundation (grant no. NNF170C0029064), the Central Denmark Region Research Fund (grant no. A3192), the Danish Medical Associations Research Foundation (grant no. 2019-3780/41), and Aarhus University, where LV is employed as a PhD fellow. The study funders were not involved in the design of the study; the collection, analysis, and interpretation of data; writing the report; and did not impose any restrictions regarding the publication of the report.
: PLP has received a speaker honorarium from Novo Nordisk A/S and Bayer A/S. PLP has received support (payments to institution) from Novo Nordisk A/S, the Novo Nordisk Foundation and Bayer A/S. KLF has received a speaker honorarium from Novo Nordisk A/S. HB has received a research grant from Glaxo Smith Kline and Vifor Pharma (paid to institution), and has received consulting fees and/or speaker honoraria from Vifor Pharma, AstraZeneca, Bayer, Boehringer Ingelheim, GSK, Galapagos, Alexion, MSD and Novo Nordisk, as well as support for attending meetings from Novartis and AstraZeneca. All other authors declare that there are no other relationships or activities that might bias, or be perceived to bias, their work.
: LV and SG contributed to the design and acquired the data, together with SSS. LV analysed and interpreted the data, and drafted and revised the manuscript. SG, SSS, SR, CL, HB, KLF, PLP and EL interpreted the data and reviewed the article critically for important intellectual content. PLP and EL were responsible for the conception of the study. All authors approved the final version to be published. LV is the guarantor of this work, and has had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.