Zhao, Lue Ping
Papadopoulos, George K.
Skyler, Jay S.
Pugliese, Alberto
Parikh, Hemang M.
Kwok, William W.
Lybrand, Terry P.
Bondinas, George P.
Moustakas, Antonis K.
Wang, Ruihan
Pyo, Chul-Woo
Nelson, Wyatt C.
Geraghty, Daniel E.
Lernmark, Åke
Funding for this research was provided by:
National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK132406)
Lund University
Article History
Received: 9 May 2024
Accepted: 24 July 2024
First Online: 1 October 2024
Acknowledgements
: The authors would like to express appreciation to the Steering Committee of TN07 in TrialNet for approving our request to access DNA samples and to thank NIDDK Central Repository for providing clinical data from both the DPT-1 and TN07. Equally, we would like to thank reviewers whose comments have substantially improved the presentation of this work.
: Clinical trial data and biospecimen samples are available through the NIDDK Central Repository portal (); clinical data from participants in DPT-1 and TN07 are available from NIDDK Central Repository (). Interested researchers are encouraged to contact corresponding authors for collaborative research on <i>HLA-DQ</i> genotype data.
: The study was supported by a grant (R01 DK132406) from National Institute of Health/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The funder played no role in study design, analysis or interpretation.
: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: LPZ, ÅL and GKP researched and analysed the data and wrote the manuscript. JSS and AP conducted the DPT-1 trial and were involved in analysis conceptualisation and result interpretation and both reviewed and edited the manuscript. HMP reviewed and analysed data, and also edited the manuscript. WWK reviewed the analysis results, expanded on implications of findings in the context of <i>DRB3</i> binding peptides and contributed to the manuscript writing. TPL reviewed results and contributed to the writing of the manuscript. DEG, RW, C-WP and WCN sequenced HLA genes using next-generation sequencing, analysed sequence data and reviewed the manuscript. GKP, AKM and GPB performed structural analysis, constructed graphical representations of selected DQ molecules and contributed to the section of the manuscript. All authors approved the version of the manuscript submitted for publication. LPZ and ÅL are guarantors of this work, had full access to all the data, and take full responsibility for the integrity of data and accuracy of data analysis.