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Article History

Received: 11 April 2024

Accepted: 12 July 2024

First Online: 15 October 2024

Acknowledgements

: We thank the organ donors and their families. We thank the Network for Pancreatic Organ Donors (nPOD) and especially thank I. Kusmartseva and M. Yang (Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, USA) for pancreatic tissue sample procurement and distribution. We also thank P.-I. Petropoulou (Institute of Diabetes Research, Helmholtz Zentrum München, Germany) for helpful suggestions to the project. We acknowledge technical support from the Imaging Core at the Canucks for Kids Childhood Diabetes Laboratory at BC Children’s Hospital Research Institute.

: Raw data and images are available upon request.

: Open Access funding enabled and organized by Projekt DEAL. This work was supported by grants from Breakthrough T1D (3-COE-2022-1103-M-B) through Breakthrough T1D Centre of Excellence at University of British Columbia and Canadian Institutes of Health and Research (CIHR PJT-153156) to CBV, a Breakthrough T1D Advanced Postdoctoral Fellowship (3-APF-2022–1141-A-N) to Y-CC, a University of British Columbia Faculty of Medicine Summer Studentship (to KG), and a career development award from Breakthrough T1D (5-CDA-2020–949-A-N) to TR-C. Research in the Rodriguez-Calvo laboratory is supported by IMI2-JU under grant agreement no. 115797 (INNODIA) and no. 945268 (INNODIA HARVEST). This Joint Undertaking receives support from the Union’s Horizon 2020 research and innovation programme and EFPIA, Breakthrough T1D and The Leona M. and Harry B. Helmsley Charitable Trust. The study sponsor/funder was not involved in the design of the study; the collection, analysis and interpretation of data; writing the report; and did not impose any restrictions regarding the publication of the report.

: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.

: PSA contributed to study design, data analysis, interpretation of data and drafted the manuscript. Y-CC contributed to the study conception and design, acquisition, analysis and interpretation of data and drafted the manuscript. YL and SB contributed to data analysis, and reviewed the manuscript. KG contributed to data acquisition and reviewed the manuscript. CBV contributed to the conception and design, interpretation of data and reviewed the manuscript. TR-C contributed to interpretation of data, and edited and reviewed the manuscript. PSA and Y-CC contributed equally to this work. All authors have approved the final version of the manuscript to be published. Both CBV and TR-C are guarantors of this study.