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Article History

Received: 11 July 2024

Accepted: 16 August 2024

First Online: 15 October 2024

Acknowledgements

: We are grateful to C. V. E. Wright (Department of Cell and Developmental Biology, Vanderbilt University, TN, USA) for providing the PDX1 antibody. We thank the Indiana University School of Medicine Transgenic Mouse core for generating one founder line of TRE-hPAK1 transgenic mice, and the City of Hope Transgenic Mouse Core (Duarte, CA, USA) for generating two additional founder lines. Human islets were provided by the City of Hope Islet Core and by the Integrated Islet Distribution Program (IIDP). Research reported in this publication included work performed in the City of Hope the Electron Microscopy Core, the Integrated Genomics Core, the Comprehensive Metabolic Phenotyping Core, and the Pathology Core supported by the National Cancer Institute of the National Institutes of Health under grant no. P30CA033572. We thank C. S. Jayasena (City of Hope, Duarte, CA, USA) for providing critical feedback and editing the manuscript.

: The raw and processed RNA-seq data and ChIP-seq data, which has been made publicly available at Gene Expression Omnibus (GEO) at , can be accessed in GSE239382.

: Open access funding provided by SCELC, Statewide California Electronic Library Consortium. This work was supported by the National Institutes of Health grants to DCT (DK067912, DK112917 and DK102233) and SD (R01DK120523). The study funders were not involved in the design of the study; the collection, analysis, and interpretation of data; writing the report; and did not impose any restrictions regarding the publication of the report.

: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.

: The study was conceptualised by DCT and MA. The funding was acquired by DCT. Experiments were performed by EMM, MA, PAG and SD. Bioinformatics analysis was performed by SB. Resources were provided by RS. The project was supervised by DCT. The original draft of this manuscript was written by DCT and MA. DCT, MA, EMM, PAG, RS, SB and SD were involved in the data analysis, discussion and editing of the manuscript. All authors approved the final version of the manuscript. DCT is the guarantor of this work and takes full responsibility for the manuscript.