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Authors
Wang, Qian https://orcid.org/0000-0001-7432-8613
Leask, Megan P. https://orcid.org/0000-0003-3199-5277
Lee, Kate https://orcid.org/0000-0001-6848-4767
Jaiswal, Jagdish https://orcid.org/0000-0002-0731-2117
Kallingappa, Prasanna https://orcid.org/0000-0002-2834-6148
Dissanayake, Waruni https://orcid.org/0000-0002-0477-9619
Puli’uvea, Chris https://orcid.org/0009-0006-4467-7744
O’Sullivan, Conor https://orcid.org/0009-0001-5254-6078
Watson, Huti https://orcid.org/0009-0007-5055-6081
Wilcox, Phillip https://orcid.org/0000-0001-8485-6962
Murphy, Rinki https://orcid.org/0000-0002-0043-2423
Merry, Troy L. https://orcid.org/0000-0001-8699-500X
Shepherd, Peter R. https://orcid.org/0000-0001-9742-5811
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Funding
Funding for this research was provided by:
Health Research Council of New Zealand (18-681)
Maurice Wilkins Centre for Molecular Biodiscovery
University of Auckland
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Article History
Received: 30 April 2024
Accepted: 19 August 2024
First Online: 18 October 2024
Acknowledgements
: He mihi nui tēnei ki ngā kai tuku taonga (We would like to thank the study participants for their time and tissue samples) and T. Merriman (University of Alabama, USA) for advice on the genetic studies and J. Krebs (University of Otago, NZ), R. Hall (University of Otago, NZ), P. Whitfield (University of Otago, NZ), H. Burden (University of Auckland, NZ) and S. Adams (University of Auckland, NZ) for input into the human phenotyping studies.
: The datasets generated from the human cohort are not publicly available due to ethical approval requirement, but are available on reasonable request. Preclinical datasets generated from this study are available from the corresponding author on reasonable request. Any requests should also include evidence they have addressed the guidelines for working with Māori in medical genomics: . All software used in the analyses were open source and are described in the Methods.
: Open Access funding enabled and organized by CAUL and its Member Institutions. This study was funded by the Health Research Council of New Zealand programme grant 18-681 and the Maurice Wilkins Centre for Molecular Biodiscovery (MWC).
: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: QW and PRS designed the research; QW, PRS, RM, PW and TLM contributed to the conception of the research and data interpretation; QW, KL, JJ, MPL, WD, PK, CO’S, HW, TLM and CP contributed to data acquisition; QW, PRS and MPL analysed the data; QW and PRS wrote the manuscript; PW, CP and HW contributed to review and editing of the manuscript. All authors provided comments on manuscript drafts and approved the final version. PRS is responsible for the integrity of the work as a whole.
