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Article History

Received: 30 July 2024

Accepted: 20 August 2024

First Online: 18 October 2024

Acknowledgements

: We thank the SCAHU staff of Angers University for taking care of the animals, the SCIAM platform, especially F. Manero, for technical assistance in electron microscopy imaging, and the staff of University Hospital Centre of Angers for analysis of clinical data of NUMEVOX cohort. Additionally, we thank the Department of Pathology of University Hospital Centre of Angers for help with the histological analyses.

: All data generated or analysed during this study are available on request from the authors.

: Open access funding provided by Université d'Angers. This work was supported by Institut National de la Santé et de la Recherche Médicale, Université d’Angers, Centre Hospitalo-Universitaire d’Angers and Fondation de France (no. 00096290). SA was a recipient of a doctoral fellowship from Conseil Départemental de Mayotte. XVG was supported by Fondation pour la Recherche Médicale (SPF201809006985).

: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.

: SA, XV-G, MP, LV, PP and SK-S conducted the experiments and acquired and analysed the data. GS, SD, SH and FG provided the human samples and acquired and analysed the clinical data. P-HD and MD contributed critically to the discussion and interpretation of data. MD and PP provided reagents. RA and MCM conceived and supervised the study. SA and MCM designed the experiments and wrote the manuscript. All authors edited and approved the final version of the manuscript. MCM is responsible for the integrity of this work as a whole.