Hostrup, Pernille E.
Schmidt, Tobias
Hellsten, Simon B.
Gerwig, Rebekka H.
Størling, Joachim https://orcid.org/0000-0002-7529-4264
Johannesen, Jesper https://orcid.org/0000-0003-2772-2567
Sulek, Karolina
Hostrup, Morten https://orcid.org/0000-0002-6201-2483
Andersen, Henrik U. https://orcid.org/0000-0001-8048-9720
Buschard, Karsten https://orcid.org/0000-0002-0126-7423
Hamid, Yasmin
Pociot, Flemming https://orcid.org/0000-0003-3274-5448
Funding for this research was provided by:
Sehested Hansen Foundation
Copenhagen University
Article History
Received: 7 June 2024
Accepted: 22 August 2024
First Online: 30 October 2024
Acknowledgements
: We thank all participants and study project members for their participation in the study, and J. Rungby (Steno Diabetes Center Copenhagen) and D. Vistisen (Steno Diabetes Center Copenhagen) for serving on the data monitoring committee.
: Data supporting the results from this study are available from the corresponding author on reasonable request.
: This study was funded by the Sehested Hansens Foundation.
: All authors declare that they have no relationships or activities that might bias, or be perceived to bias, their contribution to this study.
: All authors contributed to and approved the final version of the manuscript. PEH drafted the trial protocol, collected clinical data, performed the final statistical analyses, and wrote the first draft of the manuscript. TS and SBH made substantial contributions to the data collection process. JJ, HUA, KB, YH and FP were instrumental in the conception and design of the study. Additionally, they provided valuable feedback and engaged in intellectual discussions. RHG and JS designed and performed the human islets experiments. KS and MH performed lipidomic analysis and bioinformatics, respectively. As the principal investigator, FP provided supervision and guidance throughout all stages of this work. FP is the guarantor and takes full responsibility for the integrity and accuracy of this work.