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Authors
Chen, Yuqing
Torta, Federico
Koh, Hiromi W. L.
Benke, Peter I.
Gurung, Resham L.
Liu, Jian-Jun
Ang, Keven
Shao, Yi-Ming
Chan, Gek Cher
Choo, Jason Chon-Jun
Ching, Jianhong
Kovalik, Jean-Paul
Kalhan, Tosha
Dorajoo, Rajkumar
Khor, Chiea Chuen
Li, Yun
Tang, Wern Ee
Seah, Darren E. J.
Sabanayagam, Charumathi
Sobota, Radoslaw M.
Venkataraman, Kavita
Coffman, Thomas
Wenk, Markus R.
Sim, Xueling https://orcid.org/0000-0002-1233-7642
Lim, Su-Chi https://orcid.org/0000-0003-1742-5817
Tai, E Shyong https://orcid.org/0000-0003-2929-8966
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Funding
Funding for this research was provided by:
Singapore Ministry of Health’s National Medical Research Council (NMRC/OFLCG/001/2017)
Singapore Ministry of Health’s National Medical Research Council (MOH-001327-02)
Biomedical Research Council (NMRC/OFLCG/001/2017)
Biomedical Research Council (MOH-001327-02)
National Medical Research Council (MOH-00066)
National Medical Research Council (MOH-000714 -01)
National Medical Research Council (MOH-001327-02)
National Medical Research Council (OFLCG/001/2017)
Alexandra Health Fund (STAR grant 18203)
Alexandra Health Fund (20201)
Alexandra Health Fund (23201)
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Article History
Received: 7 May 2024
Accepted: 19 September 2024
First Online: 2 December 2024
Acknowledgements
: We thank all of the participants, study team and investigators of the Diabetic Cohort (DC), the Diabetic Nephropathy (DN) cohort and the Singapore Study of Macro-angiopathy and Micro-vascular Reactivity in Type 2 Diabetes (SMART2D) for their contributions to research.
: Summary statistics of all metabolites profiled are provided in the ESM tables. Summary statistics of the GWAS on metabolites are available in the GWAS Catalog. Data from this study may be requested through the authors via an application process and shared through an institutional data-sharing agreement.
: This research is supported by the Singapore Ministry of Health’s National Medical Research Council under its Open Fund Large Collaborative Grant (NMRC/OFLCG/001/2017 and MOH-001327-02). The Diabetic Cohort (DC) is supported by individual research and clinical scientist award schemes from the National Medical Research Council (NMRC) and the Biomedical Research Council (BMRC) of Singapore, and infrastructure funding from the Singapore Ministry of Health (Population Health Metrics and Analytics [PHMA]), National University of Singapore and National University Health System, Singapore. The Diabetic Nephropathy (DN) cohort is supported by the Alexandra Health Fund (STAR grants 18203, 20201 and 23201). The Singapore Study of Macro-angiopathy and Micro-vascular Reactivity in Type 2 Diabetes (SMART2D) is supported by NMRC grants (MOH-00066, MOH-000714 -01, MOH-001327-02 and OFLCG/001/2017) and the Alexandra Health Fund (STAR grants 18203 and 20201).
: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: YC, FT, MRW, XS, SCL and EST conceived and designed the study. YC, HWLK and RLG analysed the data. YC, FT, XS, SCL and EST drafted the manuscript. All authors contributed to the writing of the article, provided support for the analysis and interpretation of results, critically revised the article and approved the final article. XS, SCL and EST are responsible for the integrity of the work as a whole.
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