Document is current

Article History

Received: 15 September 2024

Accepted: 19 February 2025

First Online: 23 April 2025

Data availability

: The RNA-seq datasets have been submitted to the Zenodo repository and can be accessed via the following links: DOI (PPs); and DOI (SC-islets).

: Open Access funding provided by the Qatar National Library. This work was funded by grants from Sidra Medicine (SDR400217) and QBRI (QBRI-HSCI Project 1). NA, the co-first author of this article, is a PhD student with a scholarship funded by QRDI (GSRA9-L-1-0511-22008).

: SH is a co-founder and shareholder of Sequantrix GmbH and has received research funding from Novo Nordisk and Askbio. The authors declare that there are no other relationships or activities that might bias, or be perceived to bias, their work.

: BM, NA, AKE performed the experiments and analysed the data. NA and AKE conducted all revision experiments. SI and SH analysed the sequencing data. BM and EMA wrote the manuscript. EMA conceived and designed the study, supervised the project, and analysed and interpreted the data. All authors critically reviewed the article and approved the final version of the manuscript. EMA is the guarantor of this work.