Document is current

Article History

Received: 11 October 2024

Accepted: 4 March 2025

First Online: 28 April 2025

Data availability

: The raw MS data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD053022 []. The rest of the data that support the findings of this study are available from the corresponding author upon reasonable request.

: Open access funding provided by Copenhagen University. This work was generously funded by the Lundbeckfonden (R434-2023-311 to JO). The x-ray experiments were performed under approval of the SPring-8 Proposal Review Committee (2022 A1069). MS-based proteomics analyses were performed by the Proteomics Research Infrastructure at the University of Copenhagen, supported by the Novo Nordisk Foundation (grant agreement number NNF19SA0059305). The Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia, Innovación y Universidades (MCIU, MICIU/AEI/10.13039/501100011033) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (grant CEX2020-001041-zzzzS funded by MCIU).

: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work. CTAL is an employee of Novo Nordisk A/S. This position began after the work on this manuscript was complete, and the position had no influence on the results or conclusions drawn.

: CTAL, ASD and JO contributed to the study conception and design. Material preparation, data collection and analysis were performed by CTAL, RM-J, LS, EC, AB, JL, RAES, SL, HI, MC, JAM, GG, JA-C, TJH, JV, MA, VM, RH, JG, PG, MA-L, MB, RR, ASD and JO. The first draft of the manuscript was written by CTAL and JO, and all authors commented on all versions of the manuscript and approved the submitted version. JO is the guarantor of this work.