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Authors
Dekker, Esmée https://orcid.org/0000-0002-5404-1225
de Winter, Twan J. J. https://orcid.org/0000-0001-7230-3674
Muñoz Garcia, Amadeo https://orcid.org/0000-0002-8634-3244
de Graaf, Natascha https://orcid.org/0009-0005-0924-7346
Roodzant, Maaike J. https://orcid.org/0009-0002-9714-9735
de Koning, Eelco J. P. https://orcid.org/0000-0002-1232-7022
Carlotti, Françoise https://orcid.org/0000-0001-7929-8468
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Funding
Funding for this research was provided by:
Stichting Diabetes Onderzoek Nederland
Diabetes Fonds
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Article History
Received: 9 December 2024
Accepted: 10 March 2025
First Online: 5 June 2025
Acknowledgements
: We thank the pancreas donors and their families, the pancreatic islet isolation team of the LUMC, M. Zuurmond (LUMC) for creating the graphical abstract, and R. C. Hoeben and M. Rabelink (viral vector facility, LUMC) for production of the lentiviral vectors. We also thank N. de Jong and F. Lambregtse for their technical support. Parts of the data were presented at the Annual Dutch Diabetes Research Meeting in 2023.
: The data that support the findings of this study are available from the corresponding author upon reasonable request.
: FC and EJPdK have received funding from the DON Foundation, the Dutch Diabetes Research Foundation, Breakthrough T1D (formerly known as JDRF), the Bontius Foundation and the Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW) (NNF21CC0073729).
: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: ED designed and performed the experiments and wrote the manuscript. TJJdW performed differential gene expression analysis on type 2 diabetes donor datasets. AMG performed the scRNA-seq data analysis. NdG and MJR provided technical support. FC and EJPdK supervised the project, assisted in the design and interpretation of the data, and acquired the funding for the project. FC wrote the manuscript. All authors contributed to the article and approved the final version. FC is the guarantor of this work.
