Patel, Kishan https://orcid.org/0000-0002-5693-6831
Eastwood, Sophie V. https://orcid.org/0000-0002-1883-8771
Wells, Jonathan C. https://orcid.org/0000-0003-0411-8025
Chaturvedi, Nish https://orcid.org/0000-0002-6211-2775
Bridger Staatz, Charis https://orcid.org/0000-0002-2872-6968
Funding for this research was provided by:
Medical Research Council
Economic and Social Research Council
UCLH Biomedical Research Centre
Article History
Received: 13 January 2025
Accepted: 7 May 2025
First Online: 27 June 2025
Acknowledgements
: We would like to thank all families participating in the MCS.
: All MCS data used in this analysis are available from UK Data Service with an end user licence ( ).
: The Millennium Cohort Study is funded by grants from the Economic and Social Research Council to the Centre for Longitudinal Studies. SVE is funded by a UCLH BRC fellowship. NC was funded by the Medical Research Council. The funding sources had no role in the design, analysis or interpretation of these analyses or on the decision to submit for publication.
: NC reports receiving funds from AstraZeneca for serving on data safety and management committees of clinical trials sponsored by the company. The authors declare that there are no other relationships or activities that might bias, or be perceived to bias, their work.
: NC conceived the broad idea for the analysis. NC, KP, SVE and CB-S designed the study and analysis plan. All authors reviewed and interpreted tables. KP performed the statistical analysis. KP and NC drafted the paper. All authors contributed to further review and redraft of the paper. All authors approved the final version and decision to submit. NC is responsible for the integrity of the work as a whole.