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Authors
Albargothy, Mona J.
Troendle, Evan P. https://orcid.org/0000-0003-4825-4088
Laws, Ross https://orcid.org/0000-0003-3241-2344
Barabas, Peter https://orcid.org/0000-0002-8166-3476
Steel, David H. W. https://orcid.org/0000-0001-8734-3089
Taggart, Michael J. https://orcid.org/0000-0002-9981-2783
Curtis, Tim M. https://orcid.org/0000-0003-1543-2781
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Funding
Funding for this research was provided by:
Northern Ireland Health and Social Care R&D Division (STL/4748/13)
Randerson Foundation
Medical Research Council (MC_PC_15026)
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Article History
Received: 9 May 2025
Accepted: 9 July 2025
First Online: 2 October 2025
Acknowledgements
: The authors thank the staff of the Biological Services Unit at Queen’s University Belfast, UK, for their support with mouse maintenance and guidance on animal procedures. They also express their gratitude to the staff of the Electron Microscopy Unit at Newcastle University for their technical assistance with SBF-SEM and TEM sample preparation and imaging. The authors would like to gratefully acknowledge Professor Evelyne Sernagor, who sadly passed away this year, for her valued support and guidance as a member of MA’s PhD thesis committee. Evelyne’s scientific rigour and friendship will be long remembered. Some of the data presented in this study were previously shared as a platform presentation titled ‘Investigation of the Retinal Neurovascular Unit in Diabetic Retinopathy Using 3D Electron Microscopy’ at the EAsDEC meeting held in Coimbra, Portugal, 1-3 June 2023. The graphical abstract for this paper was created using BioRender. Curtis, T. (2025) .
: Links to all raw image stacks analysed in this article are available at . The MATLAB vascular BM thickness measurement script is available at the GitHub link .
: This study was supported by grants from the Randerson Foundation, Newcastle University, the Northern Ireland Health and Social Care R&D Division (STL/4748/13) and the Medical Research Council (MC_PC_15026). The funding bodies had no involvement in the study's design, data collection, analysis, interpretation or manuscript writing.
: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: TC, MT and DS conceived the project. MA, ET, RL and PB performed the experiments and analysed the data. ET wrote the MATLAB script. TC and MA drafted the manuscript with input from MT and DS. All authors reviewed the paper for intellectual content and approved the final version for publication. MA, TC, MT and DS are the guarantors of the integrity of the work.
