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Authors
Al-Selwi, Yara
Tiniakos, Dina
Richardson, Sarah J. https://orcid.org/0000-0002-1160-6062
Flaxman, Christine S.
Russell, Lydia
Coulthard, Rowan
Maheshwari, Rashmi
Dyson, Nicola https://orcid.org/0000-0002-4173-1913
Honkanen-Scott, Minna https://orcid.org/0000-0002-6761-2998
Klöppel, Günter https://orcid.org/0000-0002-6688-086X
Shaw, James A. M. https://orcid.org/0000-0002-2893-3211
Kattner, Nicole https://orcid.org/0000-0002-2930-5719
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Funding
Funding for this research was provided by:
Cystic Fibrosis Trust (SRC019)
Medical Research Council (MR/R014132/1)
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Article History
Received: 12 April 2025
Accepted: 11 July 2025
First Online: 12 October 2025
Acknowledgements
: We are grateful for the work of the TRM laboratory at Newcastle University, including input from C. Brack and B. Hunter. The authors wish to acknowledge the support of M. Palmer (University of Exeter) for his support developing the SRFG analysis pipeline. We are especially thankful to all donors and their families. The graphical abstract was created in BioRender. Kattner, N. (2025) .
: Data are available from the corresponding author upon reasonable request.
: This project was supported by the Cystic Fibrosis Trust SRC 019 and the MRC (Quality and Safety in Organ Donation Tissue Bank – Expansion to include Pancreas/Islets, Heart and Lungs) (MR/R014132/1). This project was further supported by a PhD studentship provided by Newcastle University (YAS). This study was supported by the National Institute for Health and Care Research Exeter Biomedical Research Centre (SJR, CSF, LR). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. This study was supported by the Ray Wilson Memorial Fund (NK).
: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: JAMS, NK and YAS designed the research studies and wrote the original manuscript. YAS, DT, GK, CSF, SJR, LR, RC, RM and NK performed experiments and/or acquired/analysed data. JAMS, SJR, CSF and NK supervised projects. ND and MHS performed tissue sampling for QUOD-PANC. All authors have reviewed and edited the manuscript and approved the final version. JAMS is the guarantor of this work.
