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Article History

Received: 16 October 2024

Accepted: 25 July 2025

First Online: 24 October 2025

Acknowledgements

: We thank A. Schniebs, A. Armbrüster, S. Janku (Department of Biophysics, Saarland University) and R. Nickels (Institute for Clinical and Experimental Surgery, Saarland University) for excellent technical assistance. We also thank G. Stopper (Department of Biophysics, Saarland University) for software and data analysis support.

: The complete gene list of RNA-seq data and lipidomics profile information (including lipid class, species, double bond, hydroxylation, carbon length and fatty acid profiles) are in online deposit: . All other data will be made available upon request.

: Open Access funding enabled and organized by Projekt DEAL. BM is grateful for generous support from the German Research Foundation (DFG), MO 2774/7-1 project number 508372800 and MO 2774/6-1 project number 505680640. CC was partially supported by the DFG SFB894. LPR is grateful for support from DFG TRR 219 Project ID 322900939. CM was and is supported by the Deutsche Forschungsgemeinschaft (DFG; SFB 894, Project A13; and SFB 1525, project # 453989101; Ma 2528/7-1; 8-1, project #505805397; and 9-2, project #315254108).

: CM has received speaker honoraria and has served as an advisor to AstraZeneca, Bristol Myers Squibb, Boehringer Ingelheim, Cytokinestics, Lilly and Novo Nordisk. The other authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.

: CC, MDAH, CB, AGA, AL, L-AdS, JA-C, SW, EB, TH, KvdM and LPR performed the experiments and analysed the data. CC, MAL, MB, MH, PG, MAR, MvdL, BM, EA, JD, EB and CM discussed the data, analysed and interpreted the data, and provided materials and equipment. CM and LPR acquired funding and designed the project. CC and LPR designed the experiments, supervised the project and wrote the paper. All authors read and approved the manuscript to be published. All authors listed in this manuscript fulfil the following criteria: (1) substantial contributions to the conception or design of the work; or the acquisition, analysis or interpretation of data; (2) drafting the article or reviewing it critically for important intellectual content; and (3) final approval of the version to be published. LPR is responsible for the integrity of the work as a whole.