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Article History

Received: 25 June 2025

Accepted: 10 September 2025

First Online: 26 December 2025

Acknowledgements

: We are grateful to E. Lamm of Garvan Cell Sorting Facility, and the staff of Australian Biological Resources, the Garvan Biological Testing Facility and the Garvan Histology Core for expert technical assistance. We thank M. Febbraio (Monash University) for the idea of using the CD11b-DTR mouse model, and A. Bobik (Baker Institute) for providing the mice.

: The data supporting the findings of this study are available from the corresponding author upon reasonable request.

: This work was supported by grants to TJB provided by the NHMRC (1070662), the Diabetes Australia Research Program (Y-18G-BIDT) and the Garvan Research Foundation.

: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.

: TJB developed and oversaw the study, performed analysis and wrote the manuscript from an original draft prepared by LO. LO, LT, NS, RD, AC-M and CS-P conducted experiments and performed analysis. MM, MJR, TGP, CS-P and KMI provided key technical, conceptual and/or analytical advice, and provided comments and suggestions for the final manuscript. All authors reviewed the manuscript and approved the final version of the manuscript. TJB is the final guarantor of the study and takes responsibility for its overall integrity.